Ram Savan
Overview
Explore the profile of Ram Savan including associated specialties, affiliations and a list of published articles.
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80
Citations
1916
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Recent Articles
1.
Hickson S, Brekke E, Schwerk J, Saluhke I, Zaver S, Woodward J, et al.
J Interferon Cytokine Res
. 2025 Mar;
PMID: 40079162
Alphaviruses (family Togaviridae) are a diverse group of positive-sense RNA (+ssRNA) viruses that are transmitted by arthropods and are the causative agent of several significant human and veterinary diseases. Interferon...
2.
Ulloa B, Barber-Axthelm I, Berube B, Duthie M, Reed S, Savan R, et al.
J Interferon Cytokine Res
. 2025 Feb;
PMID: 39945619
Retinoic acid-inducible gene I (RIG-I) is a critical sensor of viral RNA and is activated in response to binding to RNA containing exposed 5'-triphosphate (5'ppp) and poly-uridine to trigger innate...
3.
Gokhale N, Sam R, Somfleth K, Thompson M, Marciniak D, Smith J, et al.
Science
. 2024 Dec;
386(6728):eadl0429.
PMID: 39700280
Antiviral signaling downstream of RIG-I-like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA...
4.
Van Gelder R, Gokhale N, Genoyer E, Omelia D, Anderson S, Young H, et al.
EMBO Rep
. 2024 Nov;
26(1):16-35.
PMID: 39578552
Interferon-gamma (IFNγ) is a pleiotropic cytokine produced by natural killer (NK) cells during the early infection response. IFNγ expression is tightly regulated to mount sterilizing immunity while preventing tissue pathology....
5.
Li Y, Vyas S, Mehta I, Asada N, Dey I, Taylor T, et al.
J Exp Med
. 2024 Jul;
221(9.
PMID: 39058386
Autoantibody-mediated glomerulonephritis (AGN) arises from dysregulated renal inflammation, with urgent need for improved treatments. IL-17 is implicated in AGN and drives pathology in a kidney-intrinsic manner via renal tubular epithelial...
6.
Harioudh M, Perez J, So L, Maheshwari M, Ebert T, Hornung V, et al.
Immunity
. 2024 Jul;
57(8):1812-1827.e7.
PMID: 38955184
An important property of the host innate immune response during microbial infection is its ability to control the expression of antimicrobial effector proteins, but how this occurs post-transcriptionally is not...
7.
Harioudh M, Perez J, Chong Z, Nair S, So L, McCormick K, et al.
Immunity
. 2024 Feb;
57(3):446-461.e7.
PMID: 38423012
In response to viral infection, how cells balance translational shutdown to limit viral replication and the induction of antiviral components like interferons (IFNs) is not well understood. Moreover, how distinct...
8.
Gokhale N, Somfleth K, Thompson M, Sam R, Marciniak D, Chu L, et al.
bioRxiv
. 2023 Oct;
PMID: 37808873
Immune signaling needs to be well-regulated to promote clearance of pathogens, while preventing aberrant inflammation. Interferons (IFNs) and antiviral genes are activated by the detection of viral RNA by RIG-I-like...
9.
Smith J, Dowling J, McFadden M, Karp A, Schwerk J, Woodward J, et al.
Cell Rep
. 2023 Jul;
42(8):112805.
PMID: 37467105
Cellular stress in the form of disrupted transcription, loss of organelle integrity, or damage to nucleic acids can elicit inflammatory responses by activating signaling cascades canonically tasked with controlling pathogen...
10.
Savan R, Gale Jr M
Immunity
. 2023 Jul;
56(7):1443-1450.
PMID: 37437537
Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to...