Matthew G Stanton
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Explore the profile of Matthew G Stanton including associated specialties, affiliations and a list of published articles.
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19
Citations
1087
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Recent Articles
1.
Nelson J, Sorensen E, Mintri S, Rabideau A, Zheng W, Besin G, et al.
Sci Adv
. 2020 Jul;
6(26):eaaz6893.
PMID: 32637598
Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide range of clinical indications but requires uridine chemistry modification and/or tuning of the production process to prevent activation...
2.
Hassett K, Benenato K, Jacquinet E, Lee A, Woods A, Yuzhakov O, et al.
Mol Ther Nucleic Acids
. 2019 Feb;
15:1-11.
PMID: 30785039
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to...
3.
Stanton M
Nucleic Acid Ther
. 2018 Apr;
28(3):158-165.
PMID: 29688817
Messenger RNA is emerging as a highly versatile biological construct for creation of impactful medicines. mRNA vaccines directed toward infectious disease and cancer are in clinical development with encouraging early...
4.
Sabnis S, Kumarasinghe E, Salerno T, Mihai C, Ketova T, Senn J, et al.
Mol Ther
. 2018 Apr;
26(6):1509-1519.
PMID: 29653760
The success of mRNA-based therapies depends on the availability of a safe and efficient delivery vehicle. Lipid nanoparticles have been identified as a viable option. However, there are concerns whether...
5.
Chang W, Pei Y, Guidry E, Zewge D, Parish C, Sherer E, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(18):4513-4517.
PMID: 27503684
Single-stranded silencing RNAs (ss siRNA), while not as potent as duplex RNAs, have the potential to become a novel platform technology in RNA interference based gene silencing by virtue of...
6.
Sloman D, Noucti N, Altman M, Chen D, Mislak A, Szewczak A, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(17):4362-6.
PMID: 27491711
Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. This manuscript outlines efforts to optimize a pyrazolopyrimidine series of...
7.
Parmar R, Willoughby J, Liu J, Foster D, Brigham B, Theile C, et al.
Chembiochem
. 2016 Apr;
17(11):985-9.
PMID: 27121751
Small interfering RNA (siRNA)-mediated silencing requires siRNA loading into the RNA-induced silencing complex (RISC). Presence of 5'-phosphate (5'-P) is reported to be critical for efficient RISC loading of the antisense...
8.
Methot J, Hoffman D, Witter D, Stanton M, Harrington P, Hamblett C, et al.
ACS Med Chem Lett
. 2014 Jun;
5(4):340-5.
PMID: 24900838
The identification and in vitro and in vivo characterization of a potent SHI-1:2 are described. Kinetic analysis indicated that biaryl inhibitors exhibit slow binding kinetics in isolated HDAC1 and HDAC2...
9.
10.
Stanton M, Hubbs J, Sloman D, Hamblett C, Andrade P, Angagaw M, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(2):755-8.
PMID: 20005099
We report herein a novel series of difluoropiperidine acetic acids as modulators of gamma-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective beta-difluorination with Selectfluor. Compounds 1f...