Matthew D Troutman
Overview
Explore the profile of Matthew D Troutman including associated specialties, affiliations and a list of published articles.
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24
Citations
745
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0
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Recent Articles
1.
Quinn A, Ivosev G, Chin J, Mongillo R, Veiga C, Covey T, et al.
Anal Chem
. 2024 May;
96(21):8381-8389.
PMID: 38750648
Pharmacological screening heavily relies on the reliability of compound libraries. To ensure the accuracy of screening results, fast and reliable quality control (QC) of these libraries is essential. While liquid...
2.
Liu J, Vernikovskaya D, Bora G, Carlo A, Burchett W, Jordan S, et al.
AAPS J
. 2024 Mar;
26(3):36.
PMID: 38546903
Selective chemical inhibitors are critical for reaction phenotyping to identify drug-metabolizing enzymes that are involved in the elimination of drug candidates. Although relatively selective inhibitors are available for the major...
3.
Yazdi A, Perveen S, Dong C, Song X, Dong A, Szewczyk M, et al.
RSC Med Chem
. 2024 Mar;
15(3):1066-1071.
PMID: 38516600
We have developed a novel chemical handle (PFI-E3H1) and a chemical probe (PFI-7) as ligands for the Gid4 subunit of the human E3 ligase CTLH degradation complex. Through an efficient...
4.
Xu Y, West G, Abdelmessih M, Troutman M, Everley R
ACS Chem Biol
. 2021 Aug;
16(8):1445-1455.
PMID: 34374519
Stability proteomics techniques that do not require drug modifications have emerged as an attractive alternative to affinity purification methods in drug target engagement studies. Two representative techniques include the chemical-denaturation-based...
5.
Zhang H, Liu C, Hua W, Ghislain L, Liu J, Aschenbrenner L, et al.
Anal Chem
. 2021 Jul;
93(31):10850-10861.
PMID: 34320311
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a...
6.
DiRico K, Hua W, Liu C, Tucker J, Ratnayake A, Flanagan M, et al.
ACS Med Chem Lett
. 2020 Jun;
11(6):1101-1110.
PMID: 32550988
High-throughput experimentation (HTE) has emerged as an important tool in drug discovery, providing a platform for preparing large compound libraries and enabling swift reaction screening over wide-ranging conditions. Recent advances...
7.
Trapa P, Troutman M, Lau T, Wager T, Maurer T, Patel N, et al.
Drug Metab Dispos
. 2019 Jan;
47(4):405-411.
PMID: 30683809
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally acting or centrally restricted therapeutics. Previously, a comprehensive...
8.
Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman M, et al.
Drug Metab Dispos
. 2013 Jul;
41(10):1797-804.
PMID: 23857892
Aldehyde oxidase 1 (AOX1) is a cytosolic enzyme highly expressed in liver and plays a key role in metabolizing drugs containing aromatic azaheterocyclic substituents. Rapid metabolism catalyzed by AOX1 can...
9.
Di L, Keefer C, Scott D, Strelevitz T, Chang G, Bi Y, et al.
Eur J Med Chem
. 2012 Jul;
57:441-8.
PMID: 22840492
Metabolic stability of drug candidates are often determined in both liver microsome and hepatocyte assays. Comparison of intrinsic clearance values between the two assays provides additional information to guide drug...
10.
Wager T, Chandrasekaran R, Hou X, Troutman M, Verhoest P, Villalobos A, et al.
ACS Chem Neurosci
. 2012 Jul;
1(6):420-34.
PMID: 22778836
As part of our effort to increase survival of drug candidates and to move our medicinal chemistry design to higher probability space for success in the Neuroscience therapeutic area, we...