Matthew C J Wilce
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Explore the profile of Matthew C J Wilce including associated specialties, affiliations and a list of published articles.
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102
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2729
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Recent Articles
1.
Devkota S, Aryal P, Wilce M, Payne R, Stone M, Bhusal R
Protein Sci
. 2024 May;
33(6):e4999.
PMID: 38723106
Ticks produce chemokine-binding proteins, known as evasins, in their saliva to subvert the host's immune response. Evasins bind to chemokines and thereby inhibit the activation of their cognate chemokine receptors,...
2.
Devkota S, Aryal P, Pokhrel R, Jiao W, Perry A, Panjikar S, et al.
Nat Commun
. 2023 Jul;
14(1):4204.
PMID: 37452046
Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose application as anti-inflammatory therapeutics will require manipulation of their...
3.
Ullah T, Balka K, Ambrose R, Pepin G, Wilce M, Wilce J, et al.
mBio
. 2022 Aug;
13(4):e0206422.
PMID: 35924852
Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in...
4.
Sturre N, Colson R, Shah N, Watson G, Yang X, Wilce M, et al.
Biomedicines
. 2022 May;
10(5).
PMID: 35625882
The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity....
5.
Bhusal R, Aryal P, Devkota S, Pokhrel R, Gunzburg M, Foster S, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35217625
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects...
6.
Loughlin F, West D, Gunzburg M, Waris S, Crawford S, Wilce M, et al.
Nucleic Acids Res
. 2021 Feb;
49(5):2403-2417.
PMID: 33621982
TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon self-association of its prion-like...
7.
Goney M, Wilce M, Wilce J, Stocker W, Goodchild G, Chan K, et al.
Endocrinology
. 2020 Jun;
161(8).
PMID: 32569368
Ovarian-derived inhibin A and inhibin B (heterodimers of common α- and differing β-subunits) are secreted throughout the menstrual cycle in a discordant pattern, with smaller follicles producing inhibin B, whereas...
8.
Beckham S, Matak M, Belousoff M, Venugopal H, Shah N, Vankadari N, et al.
Nucleic Acids Res
. 2020 Jun;
48(14):8006-8021.
PMID: 32556302
The poliovirus type I IRES is able to recruit ribosomal machinery only in the presence of host factor PCBP2 that binds to stem-loop IV of the IRES. When PCBP2 is...
9.
Lee K, Tieu W, Blanco-Rodriguez B, Paparella A, Yu J, Hayes A, et al.
ACS Chem Biol
. 2019 Aug;
14(9):1990-1997.
PMID: 31407891
Here, we report the design, synthesis, and evaluation of a series of inhibitors of BPL (BPL), where the central acyl phosphate of the natural intermediate biotinyl-5'-AMP () is replaced by...
10.
Lang T, Lee J, Elgass K, Pinar A, Tate M, Aitken E, et al.
Nat Commun
. 2018 Jun;
9(1):2223.
PMID: 29884801
Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines,...