Matthew C J Wilce
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Explore the profile of Matthew C J Wilce including associated specialties, affiliations and a list of published articles.
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102
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2729
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Recent Articles
11.
Shah N, Beckham S, Wilce J, Wilce M
Nucleic Acids Res
. 2018 Jan;
46(6):3169-3186.
PMID: 29346611
RIG-I (retinoic acid inducible gene-I) is a cytosolic innate immune protein that senses viral dsRNA with a 5'-triphosphate overhang. Upon interaction with dsRNA a de-repression of the RIG-I CARD domains...
12.
Paparella A, Lee K, Hayes A, Feng J, Feng Z, Cini D, et al.
ACS Infect Dis
. 2017 Nov;
4(2):175-184.
PMID: 29131575
We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly,...
13.
Watson G, Kulkarni K, Sang J, Ma X, Gunzburg M, Perlmutter P, et al.
J Med Chem
. 2017 Oct;
60(22):9349-9359.
PMID: 29083893
Grb7 is a signaling protein with critical roles in tumor cell proliferation and migration and an established cancer therapeutic target. Here we explore chemical space to develop a new bicyclic...
14.
Waris S, Garcia-Maurino S, Sivakumaran A, Beckham S, Loughlin F, Gorospe M, et al.
Nucleic Acids Res
. 2017 Feb;
45(8):4944-4957.
PMID: 28184449
TIA-1 (T-cell restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translational repression. It mainly interacts with RNA via its second and third RNA recognition motifs (RRMs), with...
15.
Gunzburg M, Kulkarni K, Watson G, Ambaye N, Del Borgo M, Brandt R, et al.
Sci Rep
. 2016 Jun;
6:27060.
PMID: 27257138
The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a...
16.
Watson G, Gunzburg M, Ambaye N, Lucas W, Traore D, Kulkarni K, et al.
J Med Chem
. 2015 Sep;
58(19):7707-18.
PMID: 26359549
The Grb7 adaptor protein is a therapeutic target for both TNBC and HER2+ breast cancer. A nonphosphorylated cyclic peptide 1 (known as G7-18NATE) inhibits Grb7 via targeting the Grb7-SH2 domain,...
17.
Selkrig J, Belousoff M, Headey S, Heinz E, Shiota T, Shen H, et al.
Sci Rep
. 2015 Aug;
5:12905.
PMID: 26243377
The biogenesis of membranes from constituent proteins and lipids is a fundamental aspect of cell biology. In the case of proteins assembled into bacterial outer membranes, an overarching question concerns...
18.
Gunzburg M, Sivakumaran A, Pendini N, Yoon J, Gorospe M, Wilce M, et al.
Cell Cycle
. 2015 Jul;
14(17):2729-33.
PMID: 26177105
Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA...
19.
X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein
Don Paul C, Traore D, Olsen S, Devenish R, Close D, Bell T, et al.
PLoS One
. 2015 Apr;
10(4):e0123338.
PMID: 25923520
Phanta is a reversibly photoswitching chromoprotein (ΦF, 0.003), useful for pcFRET, that was isolated from a mutagenesis screen of the bright green fluorescent eCGP123 (ΦF, 0.8). We have investigated the...
20.
Salaemae W, Yap M, Wegener K, Booker G, Wilce M, Polyak S
Tuberculosis (Edinb)
. 2015 Mar;
95(3):259-66.
PMID: 25801336
Dethiobiotin synthetase (DTBS) plays a crucial role in biotin biosynthesis in microorganisms, fungi, and plants. Due to its importance in bacterial pathogenesis, and the absence of a human homologue, DTBS...