Matthew C Cane
Overview
Explore the profile of Matthew C Cane including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
443
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Recent Articles
1.
Georgiadou E, Haythorne E, Dickerson M, Lopez-Noriega L, Pullen T, da Silva Xavier G, et al.
Diabetologia
. 2020 May;
63(7):1368-1381.
PMID: 32350566
Aims/hypothesis: Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca uptake into pancreatic beta cell mitochondria potentiates or antagonises this process is still a matter of debate....
2.
Carrat G, Hu M, Nguyen-Tu M, Chabosseau P, Gaulton K, van de Bunt M, et al.
Am J Hum Genet
. 2017 Jan;
100(2):238-256.
PMID: 28132686
Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios,...
3.
Mehta Z, Fine N, Pullen T, Cane M, Hu M, Chabosseau P, et al.
Am J Physiol Endocrinol Metab
. 2016 Jun;
311(2):E488-507.
PMID: 27329800
Single nucleotide polymorphisms (SNPs) close to the VPS13C, C2CD4A and C2CD4B genes on chromosome 15q are associated with impaired fasting glucose and increased risk of type 2 diabetes. eQTL analysis...
4.
Martinez-Sanchez A, Pullen T, Chabosseau P, Zhang Q, Haythorne E, Cane M, et al.
Diabetes
. 2016 Feb;
65(5):1268-82.
PMID: 26861785
Encoding acyl-CoA thioesterase-7 (Acot7) is one of ∼60 genes expressed ubiquitously across tissues but relatively silenced, or disallowed, in pancreatic β-cells. The capacity of ACOT7 to hydrolyze long-chain acyl-CoA esters...
5.
Cane M, Parrington J, Rorsman P, Galione A, Rutter G
Cell Calcium
. 2016 Jan;
59(1):32-40.
PMID: 26769314
Ca(2+) signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (GLP-1). Whilst Ca(2+) influx through voltage-gated Ca(2+) channels on...
6.
Huang W, Cane M, Mukherjee R, Szatmary P, Zhang X, Elliott V, et al.
Gut
. 2015 Dec;
66(2):301-313.
PMID: 26642860
Objective: Caffeine reduces toxic Ca signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IPR)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of...
7.
Mitchell R, Hu M, Chabosseau P, Cane M, Meur G, Bellomo E, et al.
Mol Endocrinol
. 2015 Nov;
30(1):77-91.
PMID: 26584158
Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules. Although a common nonsynonymous polymorphism (R325W), which...
8.
Mukherjee R, Mareninova O, Odinokova I, Huang W, Murphy J, Chvanov M, et al.
Gut
. 2015 Jun;
65(8):1333-46.
PMID: 26071131
Objective: Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific drug therapy. Mitochondrial dysfunction has been...
9.
Hodson D, Tarasov A, Gimeno Brias S, Mitchell R, Johnston N, Haghollahi S, et al.
Mol Endocrinol
. 2014 Apr;
28(6):860-71.
PMID: 24766140
Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP...
10.
Huang W, Booth D, Cane M, Chvanov M, Javed M, Elliott V, et al.
Gut
. 2013 Oct;
63(8):1313-24.
PMID: 24162590
Objective: Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury and acute pancreatitis (AP). This study...