David M Booth
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Explore the profile of David M Booth including associated specialties, affiliations and a list of published articles.
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16
Citations
621
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Recent Articles
1.
Young M, Booth D, Smith D, Tigano M, Hajnoczky G, Joseph S
Front Cell Dev Biol
. 2024 Dec;
12:1473210.
PMID: 39712573
The activation of IP receptor (IPR) Ca channels generates agonist-mediated Ca signals that are critical for the regulation of a wide range of biological processes. It is therefore surprising that...
2.
Coku J, Booth D, Skoda J, Pedrotty M, Vogel J, Liu K, et al.
EMBO J
. 2022 Feb;
41(8):e108272.
PMID: 35211994
Most cancer deaths result from progression of therapy resistant disease, yet our understanding of this phenotype is limited. Cancer therapies generate stress signals that act upon mitochondria to initiate apoptosis....
3.
Booth D, Varnai P, Joseph S, Hajnoczky G
STAR Protoc
. 2022 Jan;
3(1):101119.
PMID: 35098166
This protocol describes how to visualize, detect, and analyze redox signals (oxidative bursts) at the ER-mitochondrial interface. It uses drug-inducible crosslinking to target the genetically encoded glutathione redox sensor Grx1roGFP2...
4.
Young M, Schug Z, Booth D, Yule D, Mikoshiba K, Hajnoczky G, et al.
J Biol Chem
. 2021 Nov;
298(1):101436.
PMID: 34801549
Calcium signaling is essential for regulating many biological processes. Endoplasmic reticulum inositol trisphosphate receptors (IPRs) and the mitochondrial Ca uniporter (MCU) are key proteins that regulate intracellular Ca concentration. Mitochondrial...
5.
Booth D, Varnai P, Joseph S, Hajnoczky G
Mol Cell
. 2021 Aug;
81(18):3866-3876.e2.
PMID: 34352204
The emerging role of mitochondria as signaling organelles raises the question of whether individual mitochondria can initiate heterotypic communication with neighboring organelles. Using fluorescent probes targeted to the endoplasmic-reticulum-mitochondrial interface,...
6.
Joseph S, Booth D, Young M, Hajnoczky G
Cell Calcium
. 2019 Mar;
79:89-97.
PMID: 30889512
Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role in cell death are well recognized. This review focuses on two ROS targets that are key to local Ca...
7.
Joseph S, Young M, Alzayady K, Yule D, Ali M, Booth D, et al.
J Biol Chem
. 2018 Sep;
293(45):17464-17476.
PMID: 30228182
A sensitization of inositol 1,4,5-trisphosphate receptor (IPR)-mediated Ca release is associated with oxidative stress in multiple cell types. These effects are thought to be mediated by alterations in the redox...
8.
Booth D, Enyedi B, Geiszt M, Varnai P, Hajnoczky G
Mol Cell
. 2016 Jul;
63(2):240-248.
PMID: 27397688
The ER-mitochondrial interface is central to calcium signaling, organellar dynamics, and lipid biosynthesis. The ER and mitochondrial membranes also host sources and targets of reactive oxygen species (ROS), but their...
9.
Booth D, Joseph S, Hajnoczky G
Cell Calcium
. 2016 May;
60(2):65-73.
PMID: 27209367
Recent advances in genetically encoded fluorescent probes have dramatically increased the toolkit available for imaging the intracellular environment. Perhaps the biggest improvements have been made in sensing specific reactive oxygen...
10.
Huang W, Cane M, Mukherjee R, Szatmary P, Zhang X, Elliott V, et al.
Gut
. 2015 Dec;
66(2):301-313.
PMID: 26642860
Objective: Caffeine reduces toxic Ca signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IPR)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of...