Matthew A Huggins
Overview
Explore the profile of Matthew A Huggins including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
432
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0
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Recent Articles
1.
Lucas E, Huggins M, Peng C, OConnor C, Gress A, Thefaine C, et al.
Sci Immunol
. 2024 Jun;
9(96):eadj8356.
PMID: 38941479
KLRG1 CD8 T cells persist for months after clearance of acute infections and maintain high levels of effector molecules, contributing protective immunity against systemic pathogens. Upon secondary infection, these long-lived...
2.
Dahlquist K, Huggins M, Yousefzadeh M, Soto-Palma C, Cholensky S, Pierson M, et al.
Nat Aging
. 2024 Apr;
4(7):915-925.
PMID: 38689133
By 2030, individuals 65 years of age or older will make up approximately 20% of the world's population. Older individuals are at the highest risk for mortality from infections, largely...
3.
Burger S, Stenger T, Pierson M, Sridhar A, Huggins M, Kucaba T, et al.
J Immunol
. 2023 Apr;
210(11):1740-1751.
PMID: 37074206
Microbial experience fundamentally shapes immunity, particularly during the perinatal period when the immune system is underdeveloped, and novel microbial encounters are common. Most animal models are raised in specific pathogen-free...
4.
Sjaastad F, Huggins M, Lucas E, Skon-Hegg C, Swanson W, Martin M, et al.
J Immunol
. 2022 Nov;
209(11):2149-2159.
PMID: 36426978
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding the limited translation of some preclinical findings generated using specific...
5.
Jarjour N, Wanhainen K, Peng C, Gavil N, Maurice N, Borges da Silva H, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2209021119.
PMID: 36260745
Interleukin-15 (IL-15) is often considered a central regulator of memory CD8 T cells, based primarily on studies of recirculating subsets. However, recent work identified IL-15-independent CD8 T cell memory populations,...
6.
Peng C, Huggins M, Wanhainen K, Knutson T, Lu H, Georgiev H, et al.
Immunity
. 2021 Dec;
55(1):98-114.e5.
PMID: 34932944
Elevated gene expression of the costimulatory receptor Icos is a hallmark of CD8 tissue-resident memory (Trm) T cells. Here, we examined the contribution of ICOS in Trm cell differentiation. Upon...
7.
Camell C, Yousefzadeh M, Zhu Y, Langhi Prata L, Huggins M, Pierson M, et al.
Science
. 2021 Jun;
373(6552).
PMID: 34103349
The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically ill to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced morbidity and mortality. Cellular senescence contributes to inflammation,...
8.
Georgiev H, Peng C, Huggins M, Jameson S, Hogquist K
Nat Commun
. 2021 Apr;
12(1):2308.
PMID: 33863906
Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II....
9.
Huggins M, Hamilton S
Nat Immunol
. 2020 Oct;
21(12):1482-1483.
PMID: 33122851
No abstract available.
10.
Renkema K, Huggins M, Borges da Silva H, Knutson T, Henzler C, Hamilton S
J Immunol
. 2020 Jul;
205(4):1059-1069.
PMID: 32611727
CD8 effector T cells with a CD127 KLRG1 phenotype are considered precursors to the long-lived memory pool, whereas KLRG1CD127 cells are viewed as short-lived effectors. Nevertheless, we and others have...