David Masopust
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Explore the profile of David Masopust including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Arnesen H, Birkeland S, Stendahl H, Neuhaus K, Masopust D, Boysen P, et al.
Discov Immunol
. 2025 Mar;
4(1):kyaf002.
PMID: 40065807
Introduction: Concerns regarding the translational value of preclinical mouse models have been addressed by introducing various approaches of 'naturalizing' research mice, which provide them with more diverse microbiomes and physiological...
2.
Jarjour N, Dalzell T, Maurice N, Wanhainen K, Peng C, OFlanagan S, et al.
Immunity
. 2025 Mar;
58(3):616-631.e5.
PMID: 40023156
Interleukin-7 (IL-7) is considered a critical regulator of memory CD8 T cell homeostasis. However, this is primarily based on circulating memory populations, and the cell-intrinsic requirement for IL-7 signaling during...
3.
Saavedra F, Brotto D, Joag V, Matson C, Nesmiyanov P, Herzberg M, et al.
Mucosal Immunol
. 2025 Feb;
PMID: 39988203
Emerging evidence indicates that gingival-resident helper CD4 T cells are major drivers of periodontal inflammation in response to commensal and pathogenic oral microorganisms. Whether tissue-resident memory CD8 T cells (T),...
4.
Scott M, Steier Z, Pierson M, Stolley J, OFlanagan S, Soerens A, et al.
Immunity
. 2024 Dec;
58(1):162-181.e10.
PMID: 39708817
Tissue-resident memory CD8 T (Trm) cells control infections and cancer and are defined by their lack of recirculation. Because migration is difficult to assess, residence is usually inferred by putative...
5.
Rehermann B, Graham A, Masopust D, Hamilton S
Nat Rev Immunol
. 2024 Nov;
PMID: 39562646
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. These studies have been facilitated by the genetic tractability and inbreeding of such...
6.
Metko M, Tonne J, Veliz Rios A, Thompson J, Mudrick H, Masopust D, et al.
Vaccines (Basel)
. 2024 Oct;
12(10).
PMID: 39460356
Background: Long-lived, re-activatable immunity to SARS-CoV-2 and its emerging variants will rely on T cells recognizing conserved regions of viral proteins across strains. Heterologous prime-boost regimens can elicit elevated levels...
7.
Gavil N, Cheng K, Masopust D
Immunity
. 2024 Aug;
57(8):1734-1751.
PMID: 39142275
Tissue-resident memory T (T) cells positively correlate with cancer survival, but the anti-tumor mechanisms underlying this relationship are not understood. This review reconciles these observations, summarizing concepts of T cell...
8.
Jarjour N, Dalzell T, Maurice N, Wanhainen K, Peng C, DePauw T, et al.
bioRxiv
. 2024 Jun;
PMID: 38895229
Interleukin-7 (IL-7) is considered a critical regulator of memory CD8 T cell homeostasis, but this is primarily based on analysis of circulating and not tissue-resident memory (T) subsets. Furthermore, the...
9.
Mi T, Soerens A, Alli S, Kang T, Vasandan A, Wang Z, et al.
Nat Aging
. 2024 Jun;
4(8):1053-1063.
PMID: 38867059
Chronological aging correlates with epigenetic modifications at specific loci, calibrated to species lifespan. Such 'epigenetic clocks' appear conserved among mammals, but whether they are cell autonomous and restricted by maximal...
10.
Stolley J, Scott M, OFlanagan S, Kunzli M, Matson C, Weyu E, et al.
J Immunol
. 2024 Apr;
212(11):1621-1625.
PMID: 38619284
Humans experience frequent respiratory infections. Immunology and vaccinology studies in mice are typically performed in naive specific pathogen-free animals responding to their very first respiratory challenge. We found that the...