Deepak A Deshpande
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Explore the profile of Deepak A Deshpande including associated specialties, affiliations and a list of published articles.
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Articles
87
Citations
2017
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Recent Articles
1.
Shigematsu M, Kawamura T, Deshpande D, Kirino Y
Mol Ther Nucleic Acids
. 2024 Sep;
35(3):102285.
PMID: 39220268
Chronic obstructive pulmonary disease (COPD) is the most prevalent lung disease, and macrophages play a central role in the inflammatory response in COPD. We here report a comprehensive characterization of...
2.
Javed E, Nayak A, Jannu A, Cohen A, Dewes I, Wang R, et al.
Am J Respir Cell Mol Biol
. 2024 Aug;
72(2):133-144.
PMID: 39141573
AKAPs (A-kinase-anchoring proteins) act as scaffold proteins that anchor the regulatory subunits of the cAMP-dependent PKA (protein kinase A) to coordinate and compartmentalize signaling elements and signals downstream of Gs-coupled...
3.
Dogan S, Walseth T, Guvenc Tuna B, Ucar E, Kannan M, Deshpande D
IUBMB Life
. 2024 Aug;
76(12):1223-1233.
PMID: 39135342
Cyclic ADP-ribose (cADPR) has emerged as a calcium-regulating second messenger in smooth muscle cells. CD38 protein possesses ADP-ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We...
4.
Conaway Jr S, Huang W, Hernandez-Lara M, Kane M, Penn R, Deshpande D
FASEB J
. 2024 Jul;
38(14):e23842.
PMID: 39037554
G-protein-coupled receptors (GPCRs) belonging to the type 2 taste receptors (TAS2Rs) family are predominantly present in taste cells to allow the perception of bitter-tasting compounds. TAS2Rs have also been shown...
5.
Shigematsu M, Kawamura T, Deshpande D, Kirino Y
bioRxiv
. 2024 Jul;
PMID: 38948719
Chronic obstructive pulmonary disease (COPD) is the most prevalent lung disease, and macrophages play a central role in the inflammatory response in COPD. We here report a comprehensive characterization of...
6.
Krishnan R, Kannan M, Deshpande D
AJP Rep
. 2024 May;
14(2):e162-e169.
PMID: 38784940
Superoxide anions (O ) have multiple effects on pulmonary parenchyma altering cell proliferation, cellular metabolism, and airway smooth muscle (ASM) contraction. Intracellular calcium ([Ca ] ) concentration plays a significant...
7.
Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma
Hernandez-Lara M, Richard J, Deshpande D
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(1):L3-L18.
PMID: 38742284
Signal transduction by G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and immunoreceptors converge at the activation of phospholipase C (PLC) for the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP) into inositol...
8.
Akkenepally S, Yombo D, Yerubandi S, Reddy G, Deshpande D, McCormack F, et al.
Nat Commun
. 2023 Dec;
14(1):8207.
PMID: 38081868
Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the...
9.
Singh B, Yokoyama Y, Tanaka Y, Laczko D, Deshpande D, Kambayashi T
Cell Immunol
. 2023 Nov;
393-394:104780.
PMID: 37918056
Allergic airway diseases are caused by inappropriate immune responses directed against inhaled environmental antigens. We previously reported that the inhibition of diacylglycerol (DAG) kinaseζ (DGKζ),an enzyme that terminates DAG-mediated signaling,protects...
10.
Loblundo C, Severa J, Peruggia G, Reid Black K, Chandra S, Lata H, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762267
Allergic sensitization to cannabis is an emerging public health concern and is difficult to clinically establish owing to lack of standardized diagnostic approaches. Attempts to develop diagnostic tools were largely...