Mathias J Wawer
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Explore the profile of Mathias J Wawer including associated specialties, affiliations and a list of published articles.
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18
Citations
1226
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Recent Articles
1.
Chatterji P, Xing G, Furst L, Dave K, Zhou Q, LaBarbera D, et al.
bioRxiv
. 2024 May;
PMID: 38746359
Ferroptosis is a cell death mechanism that has attracted significant attention as a potential basis for the development of new cancer therapies. Validation of ferroptosis biology in species commonly used...
2.
Sharifnia T, Wawer M, Goodale A, Lee Y, Kazachkova M, Dempster J, et al.
Nat Commun
. 2023 Apr;
14(1):1933.
PMID: 37024492
Identifying the spectrum of genes required for cancer cell survival can reveal essential cancer circuitry and therapeutic targets, but such a map remains incomplete for many cancer types. We apply...
3.
Dahlin J, Hua B, Zucconi B, Nelson Jr S, Singh S, Carpenter A, et al.
Nat Commun
. 2023 Mar;
14(1):1364.
PMID: 36914634
Robust, generalizable approaches to identify compounds efficiently with undesirable mechanisms of action in complex cellular assays remain elusive. Such a process would be useful for hit triage during high-throughput screening...
4.
Fecho K, Balhoff J, Bizon C, Byrd W, Hang S, Koslicki D, et al.
Clin Transl Sci
. 2021 Mar;
14(5):1719-1724.
PMID: 33742785
"Knowledge graphs" (KGs) have become a common approach for representing biomedical knowledge. In a KG, multiple biomedical data sets can be linked together as a graph representation, with nodes representing...
5.
Sheppard H, DallAgnese A, Park W, Shamim M, Dubrulle J, Johnson H, et al.
Cell Rep Med
. 2021 Feb;
2(1):100188.
PMID: 33521702
Chordomas are rare spinal tumors addicted to expression of the developmental transcription factor brachyury. In chordomas, brachyury is super-enhancer associated and preferentially downregulated by pharmacologic transcriptional CDK inhibition, leading to...
6.
Gerry C, Wawer M, Clemons P, Schreiber S
J Am Chem Soc
. 2019 Jun;
141(26):10225-10235.
PMID: 31184885
It is challenging to incorporate stereochemical diversity and topographic complexity into DNA-encoded libraries (DELs) because DEL syntheses cannot fully exploit the capabilities of modern synthetic organic chemistry. Here, we describe...
7.
Sharifnia T, Wawer M, Chen T, Huang Q, Weir B, Sizemore A, et al.
Nat Med
. 2019 Jan;
25(2):292-300.
PMID: 30664779
Chordoma is a primary bone cancer with no approved therapy. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic...
8.
Melillo B, Zoller J, Hua B, Verho O, Borghs J, Nelson Jr S, et al.
J Am Chem Soc
. 2018 Aug;
140(37):11784-11790.
PMID: 30133283
Target- and phenotype-agnostic assessments of biological activity have emerged as viable strategies for prioritizing scaffolds, structural features, and synthetic pathways in screening sets, with the goal of increasing performance diversity....
9.
Viswanathan S, Nogueira M, Buss C, Krill-Burger J, Wawer M, Malolepsza E, et al.
Nat Genet
. 2018 Jun;
50(7):937-943.
PMID: 29955178
Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency. Here, we surveyed genome-scale short hairpin...
10.
Bray M, Gustafsdottir S, Rohban M, Singh S, Ljosa V, Sokolnicki K, et al.
Gigascience
. 2017 Mar;
6(12):1-5.
PMID: 28327978
Background: Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse...