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Masatake Osawa

Explore the profile of Masatake Osawa including associated specialties, affiliations and a list of published articles. Areas
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Articles 30
Citations 980
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Recent Articles
1.
Motohashi T, Aoki H, Kunisada T, Osawa M
Stem Cells Dev . 2025 Jan; 34(5-6):117-126. PMID: 39834178
Direct conversion is an innovative new technology that involves the conversion of somatic cells to target cells without passing through a pluripotent state. Forced expression alone or in combination with...
2.
Li Y, Hirano S, Sato K, Osawa M, Nagaoka H
Biochemistry . 2024 Mar; 63(6):767-776. PMID: 38439718
Interferon regulatory factor 4 (IRF4) is a crucial transcription factor that plays a vital role in lymphocyte development, including in the fate-determining steps in terminal differentiation. It is also implicated...
3.
Nasrin M, Ahmed O, Han X, Nojebuzzaman M, Abo-Ahmed A, Yazawa S, et al.
Pigment Cell Melanoma Res . 2022 Nov; 36(1):53-70. PMID: 36318272
Conditional and inducible gene targeting using Cre/loxP-mediated recombination is a powerful reverse genetics approach used to study spatiotemporal gene functions in specified cell types. To enable temporal gene manipulation in...
4.
Takahashi T, Shiraishi A, Murata J, Matsubara S, Nakaoka S, Kirimoto S, et al.
Life Sci Alliance . 2021 Jul; 4(9). PMID: 34244422
Acetylcholine (ACh) signaling through activation of nicotinic and muscarinic ACh receptors regulates expression of specific genes that mediate and sustain proliferation, differentiation, and homeostasis in the intestinal crypts. This signaling...
5.
Takahashi T, Shiraishi A, Osawa M
Int Immunopharmacol . 2020 Nov; 88:106984. PMID: 33182055
Backgrounds: Recent studies have shown that various mammalian non-neuronal cells synthesize acetylcholine (ACh) in situ and operate cholinergic signaling via nicotinic and muscarinic ACh receptors (nAChRs and mAChRs). Understanding the...
6.
Otsuka H, Kimura T, Ago Y, Nakama M, Aoyama Y, Abdelkreem E, et al.
J Inherit Metab Dis . 2020 Apr; 43(5):960-968. PMID: 32279332
d-3-Hydroxy-n-butyrate dehydrogenase (BDH1; EC 1.1.1.30), encoded by BDH1, catalyzes the reversible reduction of acetoacetate (AcAc) to 3-hydroxybutyrate (3HB). BDH1 is the last enzyme of hepatic ketogenesis and the first enzyme...
7.
Kakuda K, Niwa A, Honda R, Yamaguchi K, Tomita H, Nojebuzzaman M, et al.
J Biochem . 2018 Dec; 165(4):369-378. PMID: 30561706
Disrupted-in-schizophrenia 1 (DISC1) is strongly associated with schizophrenia, but it remains elusive how the modification of the intermolecular interaction of DISC1 affects the information processing in brain. We show that...
8.
Islam S, Ueda M, Nishida E, Wang M, Osawa M, Lee D, et al.
Brain Res . 2018 Mar; 1688:81-90. PMID: 29571668
Olfaxin, which is a BNIP2 and Cdc42GAP homology (BCH) domain-containing protein, is predominantly expressed in mitral and tufted (M/T) cells in the olfactory bulb (OB). Olfaxin and Caytaxin, which share...
9.
Nagashima K, Miwa T, Soumiya H, Ushiro D, Takeda-Kawaguchi T, Tamaoki N, et al.
Sci Rep . 2017 Oct; 7(1):13500. PMID: 29044129
Human dental pulp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transplantation therapy. However, little work has been done to optimize such transplantation. In...
10.
Silberstein L, Goncalves K, Kharchenko P, Turcotte R, Kfoury Y, Mercier F, et al.
Cell Stem Cell . 2016 Aug; 19(4):530-543. PMID: 27524439
Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of...