Tomohisa Hirobe
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Explore the profile of Tomohisa Hirobe including associated specialties, affiliations and a list of published articles.
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66
Citations
382
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Recent Articles
1.
Hirobe T
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38674144
Mammalian melanin is produced in melanocytes and accumulated in melanosomes. Melanogenesis is supported by many factors derived from the surrounding tissue environment, such as the epidermis, dermis, and subcutaneous tissue,...
2.
Wakamatsu Y, Oikawa A, Obika M, Hirobe T, Ozato K
Dev Growth Differ
. 2023 Jun;
26(5):503-513.
PMID: 37281091
Four cell lines including two sublines were established from hereditary melanomas in interspecific hybrids between platyfish (Xiphophorus maculatus) carrying the Sp gene and swordtails (X. helleri) and maintained in vitro...
3.
4.
Hirobe T, Enami H
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499690
Vitiligo is a hypopigmentation disease characterized by melanocyte death in the human epidermis. However, the mechanism of vitiligo development and repigmentation is largely unknown. Dermal fiber components might play an...
5.
Hirobe T, Enami H, Nakayama A
Int J Cosmet Sci
. 2020 Dec;
43(2):211-217.
PMID: 33296514
Objective: In human skin, melanocytes and melanoblasts are mostly located in the epidermis in addition to hair follicles. In hairy skin such as mouse skin, the inter-follicular epidermis is generally...
6.
Ito S, Del Bino S, Hirobe T, Wakamatsu K
Int J Mol Sci
. 2020 Jul;
21(14).
PMID: 32698502
Alkaline hydrogen peroxide oxidation (AHPO) of eumelanin and pheomelanin, two major classes of melanin pigments, affords pyrrole-2,3,5-tricarboxylic acid (PTCA), pyrrole-2,3-dicarboxylic acid (PDCA) and pyrrole-2,3,4,5-tetracarboxylic acid (PTeCA) from eumelanin and thiazole-2,4,5-tricarboxylic...
7.
Hirobe T, Enami H, Nakayama A
Int J Dermatol
. 2020 Apr;
59(10):e369-e372.
PMID: 32346870
No abstract available.
8.
Hirobe T, Enami H
Skin Res Technol
. 2018 Nov;
25(3):299-304.
PMID: 30387525
Introduction: The classical study revealed the melanocyte density in the epidermis of many skin sites of humans. However, these data were obtained by counting melanocytes using dihydroxyphenylalanine (dopa)-treated epidermal sheets....
9.
Tanaka H, Yamashita Y, Umezawa K, Hirobe T, Ito S, Wakamatsu K
Int J Mol Sci
. 2018 Sep;
19(10).
PMID: 30249034
It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is phototoxic. A recent study using a mouse model demonstrated that PM produces reactive oxygen species (ROS) that...
10.
Hirobe T, Enami H
Int J Dermatol
. 2018 Sep;
58(2):210-217.
PMID: 30191560
Background: Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been...