Toshio Takahashi
Overview
Explore the profile of Toshio Takahashi including associated specialties, affiliations and a list of published articles.
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112
Citations
1407
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Recent Articles
1.
Takase Y, Takahashi T
Methods Mol Biol
. 2023 Dec;
2749:73-84.
PMID: 38133775
The intestinal epithelium is composed of two distinct structures, namely, the villi and crypts. The base of the crypts contains intestinal stem cells (ISCs), which support the high regenerative capacity...
2.
Sakai T, Yamamoto T, Watanabe T, Hozumi A, Shiraishi A, Osugi T, et al.
Front Endocrinol (Lausanne)
. 2023 Oct;
14:1260600.
PMID: 37842312
Invertebrates lack hypothalamic-pituitary-gonadal axis, and have acquired species-specific regulatory systems for ovarian follicle development. Ascidians are marine invertebrates that are the phylogenetically closest living relatives to vertebrates, and we have...
3.
Takase Y, Fujishima K, Takahashi T
J Vis Exp
. 2023 Apr;
(194).
PMID: 37092847
At present, organoid culture represents an important tool for in vitro studies of different biological aspects and diseases in different organs. Murine small intestinal crypts can form organoids that mimic...
4.
Ohmae S, Akazawa S, Takahashi T, Izumo T, Rogi T, Nakai M
Biochem Biophys Res Commun
. 2022 May;
615:24-30.
PMID: 35605401
Age-associated increase in ectopic fat degeneration and fibrosis in the skeletal muscle contribute to muscle degradation and weakness. Quercetin is a bioactive flavonoid with anti-inflammatory and anti-obesity effects. Thus, we...
5.
Takahashi T, Fujishima K, Kengaku M
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681571
Intestinal epithelial cells (IECs) are crucial for the digestive process and nutrient absorption. The intestinal epithelium is composed of the different cell types of the small intestine (mainly, enterocytes, goblet...
6.
Takahashi T, Shiraishi A, Murata J, Matsubara S, Nakaoka S, Kirimoto S, et al.
Life Sci Alliance
. 2021 Jul;
4(9).
PMID: 34244422
Acetylcholine (ACh) signaling through activation of nicotinic and muscarinic ACh receptors regulates expression of specific genes that mediate and sustain proliferation, differentiation, and homeostasis in the intestinal crypts. This signaling...
7.
Takahashi T
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33440882
Stem cells have extensive proliferative potential and the ability to differentiate into one or more mature cell types. The mechanisms by which stem cells accomplish self-renewal provide fundamental insight into...
8.
Takahashi T, Shiraishi A, Osawa M
Int Immunopharmacol
. 2020 Nov;
88:106984.
PMID: 33182055
Backgrounds: Recent studies have shown that various mammalian non-neuronal cells synthesize acetylcholine (ACh) in situ and operate cholinergic signaling via nicotinic and muscarinic ACh receptors (nAChRs and mAChRs). Understanding the...
9.
Tsugawa H, Kabe Y, Kanai A, Sugiura Y, Hida S, Taniguchi S, et al.
PLoS Biol
. 2020 Sep;
18(9):e3000813.
PMID: 32991574
Short-chain fatty acids (SCFAs) produced by gastrointestinal microbiota regulate immune responses, but host molecular mechanisms remain unknown. Unbiased screening using SCFA-conjugated affinity nanobeads identified apoptosis-associated speck-like protein (ASC), an adaptor...
10.
Takahashi T
Front Endocrinol (Lausanne)
. 2020 Jun;
11:339.
PMID: 32528418
Cnidarians are early-branching animals in the eukaryotic tree of life. The phylum Cnidaria are divided into five classes: Scyphozoa (true jellyfish), Cubozoa (box jellyfish), Hydrozoa (species, and ), Anthozoa (sea...