Martin Wuhr
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Explore the profile of Martin Wuhr including associated specialties, affiliations and a list of published articles.
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61
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3572
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Recent Articles
1.
Johnson A, Huang J, Marishta A, Cruz E, Mariossi A, Barshop W, et al.
Mol Cell Proteomics
. 2024 Dec;
24(2):100899.
PMID: 39725028
Multiplexed proteomics has become a powerful tool for investigating biological systems. Using balancer-peptide conjugates (e.g., TMTproC complementary ions) in the MS2 spectra for quantification circumvents the ratio distortion problem inherent...
2.
Benn G, Borrelli C, Prakaash D, Johnson A, Fideli V, Starr T, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2416426121.
PMID: 39630873
OmpA, a predominant outer membrane (OM) protein in , affects virulence, adhesion, and bacterial OM integrity. However, despite more than 50 y of research, the molecular basis for the role...
3.
Yang L, Zhu A, Aman J, Denberg D, Kilwein M, Marmion R, et al.
Dev Cell
. 2024 Aug;
59(23):3061-3071.e6.
PMID: 39208802
Extracellular-signal-regulated kinase (ERK) signaling controls development and homeostasis and is genetically deregulated in human diseases, including neurocognitive disorders and cancers. Although the list of ERK functions is vast and steadily...
4.
Arunachalam E, Keber F, Law R, Kumar C, Shen Y, Park J, et al.
bioRxiv
. 2024 Jul;
PMID: 39005310
A long-standing observation is that in fast-growing cells, respiration rate declines with increasing growth rate and is compensated by an increase in fermentation, despite respiration being more efficient than fermentation....
5.
Gupta M, Johnson A, Cruz E, Costa E, Guest R, Li S, et al.
Nat Commun
. 2024 Jul;
15(1):5890.
PMID: 39003262
Protein turnover is critical for proteostasis, but turnover quantification is challenging, and even in well-studied E. coli, proteome-wide measurements remain scarce. Here, we quantify the turnover rates of ~3200 E....
6.
Frese A, Mariossi A, Levine M, Wuhr M
iScience
. 2024 Mar;
27(4):109355.
PMID: 38510129
The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate , covering eight developmental stages...
7.
Shen Y, Dinh H, Cruz E, Chen Z, Bartman C, Xiao T, et al.
Nat Chem Biol
. 2024 Mar;
20(9):1123-1132.
PMID: 38448734
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolysis...
8.
Keber F, Nguyen T, Mariossi A, Brangwynne C, Wuhr M
Nat Cell Biol
. 2024 Feb;
26(3):346-352.
PMID: 38424273
Compartmentalization is an essential feature of eukaryotic life and is achieved both via membrane-bound organelles, such as mitochondria, and membrane-less biomolecular condensates, such as the nucleolus. Known biomolecular condensates typically...
9.
Kafri M, Patena W, Martin L, Wang L, Gomer G, Ergun S, et al.
Cell
. 2023 Dec;
186(25):5638-5655.e25.
PMID: 38065083
Photosynthesis is central to food production and the Earth's biogeochemistry, yet the molecular basis for its regulation remains poorly understood. Here, using high-throughput genetics in the model eukaryotic alga Chlamydomonas...
10.
Shvartsman S, McFann S, Wuhr M, Rubinstein B
J Biol Chem
. 2023 Sep;
299(11):105234.
PMID: 37690685
The extracellular signal-regulated kinase (ERK) controls multiple critical processes in the cell and is deregulated in human cancers, congenital abnormalities, immune diseases, and neurodevelopmental syndromes. Catalytic activity of ERK requires...