Aaron C Groen
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Explore the profile of Aaron C Groen including associated specialties, affiliations and a list of published articles.
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26
Citations
1264
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Recent Articles
1.
Aasted M, Groen A, Keane J, Dabelsteen S, Tan E, Schnabel J, et al.
Mol Cancer Ther
. 2023 Jul;
22(10):1204-1214.
PMID: 37451822
The lack of antibodies with sufficient cancer selectivity is currently limiting the treatment of solid tumors by immunotherapies. Most current immunotherapeutic targets are tumor-associated antigens that are also found in...
2.
Groen A, Mitchison T
Methods Mol Biol
. 2016 May;
1413:35-45.
PMID: 27193841
For many years, microtubule research has depended on tubulin purified from cow and pig brains, which may not be ideal for experiments using proteins or extracts from non-brain tissues and...
3.
Wuhr M, Guttler T, Peshkin L, McAlister G, Sonnett M, Ishihara K, et al.
Curr Biol
. 2015 Oct;
25(20):2663-71.
PMID: 26441354
The composition of the nucleoplasm determines the behavior of key processes such as transcription, yet there is still no reliable and quantitative resource of nuclear proteins. Furthermore, it is still...
4.
Field C, Groen A, Nguyen P, Mitchison T
Mol Biol Cell
. 2015 Aug;
26(20):3628-40.
PMID: 26310438
Mitotic spindles specify cleavage planes in early embryos by communicating their position and orientation to the cell cortex using microtubule asters that grow out from the spindle poles during anaphase....
5.
Nguyen P, Field C, Groen A, Mitchison T, Loose M
Methods Cell Biol
. 2015 May;
128:223-241.
PMID: 25997350
Cell division in prokaryotes and eukaryotes is commonly initiated by the well-controlled binding of proteins to the cytoplasmic side of the cell membrane. However, a precise characterization of the spatiotemporal...
6.
Ishihara K, Nguyen P, Groen A, Field C, Mitchison T
Proc Natl Acad Sci U S A
. 2014 Dec;
111(50):17715-22.
PMID: 25468969
A major challenge in cell biology is to understand how nanometer-sized molecules can organize micrometer-sized cells in space and time. One solution in many animal cells is a radial array...
7.
Nguyen P, Groen A, Loose M, Ishihara K, Wuhr M, Field C, et al.
Science
. 2014 Oct;
346(6206):244-7.
PMID: 25301629
During animal cell division, the cleavage furrow is positioned by microtubules that signal to the actin cortex at the cell midplane. We developed a cell-free system to recapitulate cytokinesis signaling...
8.
Ishihara K, Nguyen P, Wuhr M, Groen A, Field C, Mitchison T
Philos Trans R Soc Lond B Biol Sci
. 2014 Jul;
369(1650).
PMID: 25047608
The large cells in early vertebrate development face an extreme physical challenge in organizing their cytoplasm. For example, amphibian embryos have to divide cytoplasm that spans hundreds of micrometres every...
9.
Groen A, Ngyuen P, Field C, Ishihara K, Mitchison T
Methods Enzymol
. 2014 Mar;
540:417-33.
PMID: 24630120
Undiluted cytoplasmic extract prepared from unfertilized Xenopus laevis eggs by low-speed centrifugation (CSF extracts) is useful for reconstitution of egg microtubule dynamics and meiosis-II spindle organization, but it suffers limitations...
10.
Field C, Nguyen P, Ishihara K, Groen A, Mitchison T
Methods Enzymol
. 2014 Mar;
540:399-415.
PMID: 24630119
We report optimized methods for preparing Xenopus egg extracts without cytochalasin D, that we term "actin-intact egg extract." These are undiluted egg cytoplasm that contains abundant organelles, and glycogen which...