Martin R Edelmann
Overview
Explore the profile of Martin R Edelmann including associated specialties, affiliations and a list of published articles.
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15
Citations
90
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Recent Articles
1.
Edelmann M, Sladojevich F, Husbands S, Otteneder M, Blagbrough I
J Labelled Comp Radiopharm
. 2024 Nov;
67(12-13):410-424.
PMID: 39543953
The rise of nucleic acid-based therapeutics continues apace. At the same time, the need for radiolabelled oligonucleotides for determination of spatial distribution is increasing. Complex molecular structures with mostly multiple...
2.
Opolka-Hoffmann E, Edelmann M, Otteneder M, Hauri S, Jordan G, Schrag P, et al.
AAPS J
. 2024 Mar;
26(2):33.
PMID: 38478197
The clinical use of therapeutic monoclonal antibodies (mAbs) for the treatment of cancer, inflammation, and other indications has been successfully established. A critical aspect of drug-antibody pharmacokinetics is immunogenicity, which...
3.
Edelmann M, Bredack C, Belli S, Mohr P, Imhoff M, Reggiani F, et al.
Bioconjug Chem
. 2023 Sep;
34(10):1882-1893.
PMID: 37710950
The pretargeting approach separates the biological half-life of an antibody from the physical half-life of the radioisotope label, providing a strategy for reducing the radiation burden. A widely explored pretargeting...
4.
Edelmann M, Erny J, Guba W, Hierl M
ACS Omega
. 2023 Jan;
8(2):2367-2376.
PMID: 36687043
The human neuropeptide neuromedin S (NMS) consists of 33 amino acids. The introduction of tritium atoms into NMS has not been described so far. This represents a gap for using...
5.
Bredack C, Edelmann M, Borroni E, Gobbi L, Honer M
Pharmaceuticals (Basel)
. 2022 Dec;
15(12).
PMID: 36558900
Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels-Alder (IEDDA) reaction between a tetrazine (Tz) and a -cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies. The advantages of using...
6.
Edelmann M
RSC Adv
. 2022 Nov;
12(50):32383-32400.
PMID: 36425706
Radiolabelling small molecules with beta-emitters has been intensively explored in the last decades and novel concepts for the introduction of radionuclides continue to be reported regularly. New catalysts that induce...
7.
He Y, Grether U, Taddio M, Meier C, Keller C, Edelmann M, et al.
Eur J Med Chem
. 2022 Sep;
243:114750.
PMID: 36137365
Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a...
8.
Edelmann M, Hauri S
PLoS One
. 2021 Sep;
16(9):e0257342.
PMID: 34529712
Labelling of therapeutic antibodies with radionuclides or fluorophores is routinely used to study their pharmacokinetic properties. A critical assumption in utilizing labelled therapeutic antibodies is that the label has no...
9.
Edelmann M, Muser T
Bioconjug Chem
. 2021 Apr;
32(5):1027-1033.
PMID: 33909418
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. -Substituted maleimides containing the hydroxy functionality are -methylated in a three-step synthesis route, including...
10.
Schadt S, Hauri S, Lopes F, Edelmann M, Staack R, Villasenor R, et al.
Drug Metab Dispos
. 2019 Nov;
47(12):1443-1456.
PMID: 31748266
For therapeutic proteins, the currently established standard development path generally does not foresee biotransformation studies by default because it is well known that the clearance of therapeutic proteins proceeds via...