Michael B Otteneder
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Explore the profile of Michael B Otteneder including associated specialties, affiliations and a list of published articles.
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19
Citations
246
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Recent Articles
1.
Edelmann M, Sladojevich F, Husbands S, Otteneder M, Blagbrough I
J Labelled Comp Radiopharm
. 2024 Nov;
67(12-13):410-424.
PMID: 39543953
The rise of nucleic acid-based therapeutics continues apace. At the same time, the need for radiolabelled oligonucleotides for determination of spatial distribution is increasing. Complex molecular structures with mostly multiple...
2.
Opolka-Hoffmann E, Edelmann M, Otteneder M, Hauri S, Jordan G, Schrag P, et al.
AAPS J
. 2024 Mar;
26(2):33.
PMID: 38478197
The clinical use of therapeutic monoclonal antibodies (mAbs) for the treatment of cancer, inflammation, and other indications has been successfully established. A critical aspect of drug-antibody pharmacokinetics is immunogenicity, which...
3.
Van De Vyver A, Walz A, Heins M, Abdolzade-Bavil A, Kraft T, Waldhauer I, et al.
Front Pharmacol
. 2022 Sep;
13:958543.
PMID: 36105215
Monoclonal antibodies play an important role in the treatment of various diseases. However, the development of these drugs against neurological disorders where the drug target is located in the brain...
4.
Khaowroongrueng V, Jadhav S, Syed M, Akbar M, Gertz M, Otteneder M, et al.
J Pharm Sci
. 2021 Apr;
110(8):3061-3068.
PMID: 33819461
R7072 is a fully human monoclonal antibody (mAb) exerting anti-tumor activity via blockade of insulin like growth factor 1 receptor. The tumoral interstitial concentrations are anticipated to be better surrogates...
5.
Edelmann M, Kettenberger H, Knaupp A, Schlothauer T, Otteneder M
J Labelled Comp Radiopharm
. 2019 Aug;
62(11):751-757.
PMID: 31369163
The number of therapeutic antibodies in research and development as well as their complexity increases from year to year. Novel therapeutic protein formats, such as Fc-fusions, bispecific, or multivalent antibodies,...
6.
An B, Zhang M, Pu J, Shen S, Qu Y, Chen Y, et al.
Anal Chem
. 2019 Feb;
91(5):3475-3483.
PMID: 30712341
Sensitive and high-throughput measurement of biotherapeutics and biomarkers in plasma and tissues is critical for protein-drug development. Enrichment of target signature peptide (SP) after sample digestion permits sensitive LC-MS-based protein...
7.
Kratochwil N, R Dueker S, Muri D, Senn C, Yoon H, Yu B, et al.
PLoS One
. 2018 Oct;
13(10):e0205435.
PMID: 30332475
New therapeutic biological entities such as bispecific antibodies targeting tissue or specific cell populations form an increasingly important part of the drug development portfolio. However, these biopharmaceutical agents bear the...
8.
Eigenmann M, Karlsen T, Krippendorff B, Tenstad O, Fronton L, Otteneder M, et al.
J Physiol
. 2017 Sep;
595(24):7311-7330.
PMID: 28960303
Key Points: For therapeutic antibodies, total tissue concentrations are frequently reported as a lump sum measure of the antibody in residual plasma, interstitial fluid and cells. In terms of correlating...
9.
Eigenmann M, Fronton L, Grimm H, Otteneder M, Krippendorff B
MAbs
. 2017 Jun;
9(6):1007-1015.
PMID: 28613103
Monoclonal antibodies are an important therapeutic entity, and knowledge of antibody pharmacokinetics has steadily increased over the years. Despite this effort, little is known about the extent of IgG antibody...
10.
Wilkinson D, Southall R, Li M, Wright L, Corfield L, Heeley T, et al.
AAPS J
. 2017 May;
19(4):1163-1174.
PMID: 28474310
The importance of aldehyde oxidase (AOX) is becoming increasingly recognized in the prediction of human pharmacokinetic parameters from animal data. The objectives of these studies were to ascertain whether an...