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Martin Meschkat

Explore the profile of Martin Meschkat including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 233
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Recent Articles
1.
Sobierajski E, Czubay K, Beemelmans C, Beemelmans C, Meschkat M, Uhlenkamp D, et al.
J Comp Neurol . 2024 Dec; 532(12):e70011. PMID: 39660539
The development of the brain's vascular system is a predominantly prenatal process in mammalian species and is required for neurogenesis and further brain development. Our recent work on fetal pig...
2.
Ho K, Candat A, Scarpetta V, Faucourt M, Weill S, Salio C, et al.
Dev Cell . 2023 Oct; 58(23):2641-2651.e6. PMID: 37890489
Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and...
3.
Stiekema M, Houben F, Verheyen F, Borgers M, Menzel J, Meschkat M, et al.
Front Cell Dev Biol . 2022 Jul; 10:914286. PMID: 35784476
Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds. We...
4.
Buscham T, Eichel-Vogel M, Steyer A, Jahn O, Strenzke N, Dardawal R, et al.
Elife . 2022 Mar; 11. PMID: 35274615
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown. Here, we find that...
5.
Meschkat M, Steyer A, Weil M, Kusch K, Jahn O, Piepkorn L, et al.
Nat Commun . 2022 Mar; 13(1):1163. PMID: 35246535
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure...
6.
Berghoff S, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, et al.
Nat Neurosci . 2020 Dec; 24(1):47-60. PMID: 33349711
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion...
7.
Moore S, Meschkat M, Ruhwedel T, Trevisiol A, Tzvetanova I, Battefeld A, et al.
Nat Commun . 2020 Oct; 11(1):5497. PMID: 33127910
Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains...
8.
Weil M, Ruhwedel T, Meschkat M, Sadowski B, Mobius W
Methods Mol Biol . 2019 Mar; 1936:343-375. PMID: 30820909
In this chapter, we describe protocols to study different aspects of oligodendrocytes and myelin using electron microscopy. First, we describe in detail how to prepare central nervous system tissue routinely...
9.
Neumann J, Dash-Wagh S, Jungling K, Tsai T, Meschkat M, Rak A, et al.
Brain Struct Funct . 2014 Apr; 220(4):1935-50. PMID: 24728870
The 30-amino acid peptide Y-P30, generated from the N-terminus of the human dermcidin precursor protein, has been found to promote neuronal survival, cell migration and neurite outgrowth by enhancing the...