Hauke B Werner
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Explore the profile of Hauke B Werner including associated specialties, affiliations and a list of published articles.
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73
Citations
2312
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Recent Articles
1.
Bin J, Emberley K, Buscham T, Eichel-Vogel M, Doan R, Steyer A, et al.
bioRxiv
. 2025 Jan;
PMID: 39829751
Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linearly with increasing...
2.
Markusson S, Raasakka A, Schroder M, Sograte-Idrissi S, Rahimi A, Asadpour O, et al.
J Neurochem
. 2024 Dec;
169(1):e16274.
PMID: 39655780
2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, and its loss in mice and humans causes neurodegeneration. Additionally, CNPase is frequently used as a...
3.
Garg V, Andre S, Heyer L, Kracht G, Ruhwedel T, Scholz P, et al.
Open Biol
. 2024 Nov;
14(11):240100.
PMID: 39503232
Hereditary spastic paraplegias (HSPs) are a diverse set of neurological disorders characterized by progressive spasticity and weakness in the lower limbs caused by damage to the axons of the corticospinal...
4.
Siems S, Gargareta V, Schadt L, Daguano Gastaldi V, Jung R, Piepkorn L, et al.
Glia
. 2024 Sep;
73(1):38-56.
PMID: 39344832
The molecules that constitute myelin are critical for the integrity of axon/myelin-units and thus speed and precision of impulse propagation. In the CNS, the protein composition of oligodendrocyte-derived myelin has...
5.
Gargareta V, Berghoff S, Krauter D, Hummert S, Marshall-Phelps K, Mobius W, et al.
Glia
. 2024 Jun;
72(9):1572-1589.
PMID: 38895764
The velocity of axonal impulse propagation is facilitated by myelination and axonal diameters. Both parameters are frequently impaired in peripheral nerve disorders, but it is not known if the diameters...
6.
Markusson S, Raasakka A, Schroder M, Sograte-Idrissi S, Rahimi A, Asadpour O, et al.
bioRxiv
. 2024 Jun;
PMID: 38826303
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, frequently used as a marker antigen for myelinating cells. The catalytic activity of CNPase, the 3'-hydrolysis...
7.
Spate E, Zhou B, Sun T, Kusch K, Asadollahi E, Siems S, et al.
Glia
. 2024 Apr;
72(8):1374-1391.
PMID: 38587131
Oligodendrocytes and astrocytes are metabolically coupled to neuronal compartments. Pyruvate and lactate can shuttle between glial cells and axons via monocarboxylate transporters. However, lactate can only be synthesized or used...
8.
Looser Z, Faik Z, Ravotto L, Zanker H, Jung R, Werner H, et al.
Nat Neurosci
. 2024 Jan;
27(3):433-448.
PMID: 38267524
The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs). To determine how OLs detect axonal spiking and how rapid axon-OL metabolic coupling is regulated in the white...
9.
Depp C, Sun T, Sasmita A, Spieth L, Berghoff S, Nazarenko T, et al.
Nature
. 2023 May;
618(7964):349-357.
PMID: 37258678
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects...
10.
Kramer-Albers E, Werner H
Nat Rev Neurosci
. 2023 May;
24(8):474-486.
PMID: 37258632
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell communication in the nervous system, mediating tissue homeostasis. EVs influence the physiology of their target cells via horizontal transfer...