Martin Houweling
Overview
Explore the profile of Martin Houweling including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
589
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Recent Articles
1.
Haaker M, Chang J, Chung B, Pieper T, Noe F, Wang T, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Feb;
:101472.
PMID: 39892785
Background & Aims: Following liver damage, ductular reaction often coincides with liver fibrosis. Proliferation of hepatic progenitor cells is observed in ductular reaction, whereas activated hepatic stellate cells (HSCs) are...
2.
Sarink M, Mykytyn A, Jedidi A, Houweling M, Brouwers J, Ruijter G, et al.
Int J Parasitol
. 2024 Nov;
55(1):35-44.
PMID: 39490506
Acanthamoebae, pathogenic free-living amoebae, can cause Granulomatous Amoebic Encephalitis (GAE) and keratitis, and for both types of infection, no adequate treatment options are available. As the metabolism of pathogens is...
3.
Haaker M, Goossens V, Hoogland N, van Doorne H, Wang Z, Jansen J, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2024 Jul;
1869(7):159540.
PMID: 39068984
Lecithin:retinol acyltransferase (LRAT) is the main enzyme producing retinyl esters (REs) in quiescent hepatic stellate cells (HSCs). When cultured on stiff plastic culture plates, quiescent HSCs activate and lose their...
4.
Molenaar M, Haaker M, Vaandrager A, Houweling M, Helms J
J Biol Chem
. 2023 Feb;
299(4):103042.
PMID: 36803964
Hepatic stellate cells (HSCs) are liver-resident cells best known for their role in vitamin A storage under physiological conditions. Upon liver injury, HSCs activate into myofibroblast-like cells, a key process...
5.
Moreno E, Matondo A, Bongiovanni L, van de Lest C, Molenaar M, Toussaint M, et al.
Liver Int
. 2022 Aug;
42(11):2442-2452.
PMID: 35924448
The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver-specific deletion of Pten in mice results in the hyper-activation PI3K/AKT signalling accompanied by enhanced genome duplication...
6.
Molenaar M, Yadav K, Toulmay A, Wassenaar T, Mari M, Caillon L, et al.
J Cell Biol
. 2021 Jul;
220(10).
PMID: 34323918
Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine the site of lipid droplet biogenesis and...
7.
Bexkens M, Houweling M, Burgers P, Luider T, Tielens A, van Hellemond J
Chem Phys Lipids
. 2020 Aug;
232:104951.
PMID: 32795466
Toll-like receptor 2 (TLR2) is an important pattern recognition receptor on the surface of host immune cells that binds a variety of ligands that are released by microorganisms as well...
8.
Haaker M, Kruitwagen H, Vaandrager A, Houweling M, Penning L, Molenaar M, et al.
J Vet Intern Med
. 2019 Dec;
34(1):132-138.
PMID: 31830357
Background: Hepatic lipidosis is increasing in incidence in the Western world, with cats being particularly sensitive. When cats stop eating and start utilizing their fat reserves, free fatty acids (FFAs)...
9.
Bexkens M, Mebius M, Houweling M, Brouwers J, Tielens A, van Hellemond J
Int J Parasitol
. 2019 Jun;
49(8):647-656.
PMID: 31170410
Adult schistosomes, parasitic flatworms that cause the tropical disease schistosomiasis, have always been considered to be homolactic fermenters and, in their energy metabolism, strictly dependent on carbohydrates. However, more recent...
10.
Tuohetahuntila M, Molenaar M, Spee B, Brouwers J, Wubbolts R, Houweling M, et al.
J Biol Chem
. 2017 Jun;
292(30):12436-12448.
PMID: 28615446
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and...