Martijn R Molenaar
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Explore the profile of Martijn R Molenaar including associated specialties, affiliations and a list of published articles.
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20
Citations
325
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Recent Articles
1.
Buglakova E, Ekelof M, Schwaiger-Haber M, Schlicker L, Molenaar M, Shahraz M, et al.
Nat Metab
. 2024 Sep;
6(9):1695-1711.
PMID: 39251875
While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the single-cell level remains a challenge. Here we present C-SpaceM, a method for spatial single-cell isotope tracing that...
2.
Buglakova E, Ekelof M, Schwaiger-Haber M, Schlicker L, Molenaar M, Mohammed S, et al.
bioRxiv
. 2024 Mar;
PMID: 38464218
Metabolism has emerged as a key factor in homeostasis and disease including cancer. Yet, little is known about the heterogeneity of metabolic activity of cancer cells due to the lack...
3.
Molenaar M, Haaker M, Vaandrager A, Houweling M, Helms J
J Biol Chem
. 2023 Feb;
299(4):103042.
PMID: 36803964
Hepatic stellate cells (HSCs) are liver-resident cells best known for their role in vitamin A storage under physiological conditions. Upon liver injury, HSCs activate into myofibroblast-like cells, a key process...
4.
Ni Z, Wolk M, Jukes G, Mendivelso Espinosa K, Ahrends R, Aimo L, et al.
Nat Methods
. 2022 Dec;
20(2):193-204.
PMID: 36543939
Progress in mass spectrometry lipidomics has led to a rapid proliferation of studies across biology and biomedicine. These generate extremely large raw datasets requiring sophisticated solutions to support automated data...
5.
Molenaar M, Shahraz M, Delafiori J, Eisenbarth A, Ekelof M, Rappez L, et al.
Front Mol Biosci
. 2022 Dec;
9:1021889.
PMID: 36504713
Imaging mass spectrometry (MS) is becoming increasingly applied for single-cell analyses. Multiple methods for imaging MS-based single-cell metabolomics were proposed, including our recent method SpaceM. An important step in imaging...
6.
Moreno E, Matondo A, Bongiovanni L, van de Lest C, Molenaar M, Toussaint M, et al.
Liver Int
. 2022 Aug;
42(11):2442-2452.
PMID: 35924448
The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver-specific deletion of Pten in mice results in the hyper-activation PI3K/AKT signalling accompanied by enhanced genome duplication...
7.
Perez-Marti A, Ramakrishnan S, Li J, Dugourd A, Molenaar M, De La Motte L, et al.
Elife
. 2022 May;
11.
PMID: 35550039
In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and...
8.
Molenaar M, Yadav K, Toulmay A, Wassenaar T, Mari M, Caillon L, et al.
J Cell Biol
. 2021 Jul;
220(10).
PMID: 34323918
Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine the site of lipid droplet biogenesis and...
9.
Sirati N, Popova B, Molenaar M, Verhoek I, Braus G, Kaloyanova D, et al.
J Mol Biol
. 2021 Jul;
433(19):167162.
PMID: 34298062
Many proteins that can assemble into higher order structures termed amyloids can also concentrate into cytoplasmic inclusions via liquid-liquid phase separation. Here, we study the assembly of human Golgi-Associated plant...
10.
Kyle J, Aimo L, Bridge A, Clair G, Fedorova M, Helms J, et al.
Metabolomics
. 2021 Jun;
17(6):55.
PMID: 34091802
Background: Improvements in mass spectrometry (MS) technologies coupled with bioinformatics developments have allowed considerable advancement in the measurement and interpretation of lipidomics data in recent years. Since research areas employing...