Martin H Kang
Overview
Explore the profile of Martin H Kang including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
496
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0
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Recent Articles
1.
Kang M, Thomas S, Westley C, Blouin T, Xu L, Chan Y, et al.
Am J Respir Cell Mol Biol
. 2025 Jan;
PMID: 39805087
Surfactant protein-B (SP-B) deficiency is a lethal neonatal respiratory disease with few therapeutic options. Gene therapy using adeno-associated viruses (AAV) to deliver human cDNA (AAV-hSPB) can improve survival in a...
2.
Thomas S, Domm J, van Vloten J, Xu L, Vadivel A, Yates J, et al.
Mol Ther
. 2023 Oct;
31(12):3457-3477.
PMID: 37805711
Surfactant protein B (SP-B) deficiency is a rare genetic disease that causes fatal respiratory failure within the first year of life. Currently, the only corrective treatment is lung transplantation. Here,...
3.
Kang M, Hu J, Pratt R, Hodgkinson C, Asokan A, Dzau V
Biochem Biophys Res Commun
. 2020 Sep;
533(1):9-16.
PMID: 32917363
Following heart injury, cardiomyocytes, are lost and are not regenerated. In their place, fibroblasts invade the dead tissue where they generate a scar, which reduces cardiac function. We and others...
4.
Kang M, van Lieshout L, Xu L, Domm J, Vadivel A, Renesme L, et al.
Nat Commun
. 2020 Aug;
11(1):3929.
PMID: 32764559
Surfactant protein B (SP-B) deficiency is an autosomal recessive disorder that impairs surfactant homeostasis and manifests as lethal respiratory distress. A compelling argument exists for gene therapy to treat this...
5.
Jan A, Karasinska J, Kang M, de Haan W, Ruddle P, Kaur A, et al.
Neurosci Lett
. 2015 May;
598:66-72.
PMID: 25957561
The ATP-binding cassette transporter A1 (ABCA1) is a membrane bound protein that serves to efflux cholesterol and phospholipids onto lipid poor apolipoproteins during HDL biogenesis. Increasing the expression and activity...
6.
Hodgkinson C, Kang M, Dal-Pra S, Mirotsou M, Dzau V
Circ Res
. 2015 May;
116(10):1700-11.
PMID: 25953925
The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the...
7.
Brunham L, Kang M, Van Karnebeek C, Sadananda S, Collins J, Zhang L, et al.
JIMD Rep
. 2014 Oct;
18:51-62.
PMID: 25308558
Tangier disease is a rare, autosomal recessive disorder caused by mutations in the ABCA1 gene and is characterized by near absence of plasma high-density lipoprotein cholesterol, accumulation of cholesterol in...
8.
de Haan W, Bhattacharjee A, Ruddle P, Kang M, Hayden M
J Lipid Res
. 2014 Jan;
55(3):516-23.
PMID: 24443560
Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been...
9.
Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145
Kang M, Zhang L, Wijesekara N, de Haan W, Butland S, Bhattacharjee A, et al.
Arterioscler Thromb Vasc Biol
. 2013 Oct;
33(12):2724-32.
PMID: 24135019
Objective: The ATP-binding cassette transporter A1 (ABCA1) protein maintains cellular cholesterol homeostasis in several different tissues. In the liver, ABCA1 is crucial for high-density lipoprotein biogenesis, and in the pancreas...
10.
Wijesekara N, Zhang L, Kang M, Abraham T, Bhattacharjee A, Warnock G, et al.
Diabetes
. 2012 Feb;
61(3):653-8.
PMID: 22315319
Changes in cellular cholesterol affect insulin secretion, and β-cell-specific deletion or loss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) result in impaired glucose tolerance and β-cell...