Martin Clynes
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Explore the profile of Martin Clynes including associated specialties, affiliations and a list of published articles.
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195
Citations
3183
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Recent Articles
1.
Costello A, Lao N, Clynes M, Barron N
Methods Mol Biol
. 2024 Oct;
2853:71-84.
PMID: 39460915
MicroRNAs (miRNAs) are small, noncoding RNAs of about 22 nucleotides in length and have proven to be useful targets for genetic modifications for desirable phenotypes in the biotech industry. The...
2.
Capella Roca B, Meiller J, Doolan P, Clynes M
Methods Mol Biol
. 2024 Oct;
2853:1-6.
PMID: 39460910
We describe the preparation of two cell culture media formulations for the culture in suspension of Chinese hamster ovary (CHO) cell lines. The first medium, Cell growth SFM Medium, is...
3.
Tzani I, Castro-Rivadeneyra M, Kelly P, Strasser L, Zhang L, Clynes M, et al.
Nat Commun
. 2024 Oct;
15(1):8605.
PMID: 39366928
Chinese hamster ovary (CHO) cells are used to produce almost 90% of therapeutic monoclonal antibodies (mAbs) and antibody fusion proteins (Fc-fusion). The annotation of non-canonical translation events in these cellular...
4.
Allen-Coyle T, Capella Roca B, Costello A, Barron N, Keenan J, Clynes M, et al.
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38891854
MicroRNAs (miRNAs) regulate approximately one-third of all human genes. The dysregulation of miRNAs has been implicated in the development of numerous human diseases, including cancers. In our investigation focusing on...
5.
Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Roy Chaudhuri T, Lin Q, Stachowiak E, Rosario S, Spernyak J, Ma W, et al.
Clin Cancer Res
. 2024 Jan;
30(7):1367-1381.
PMID: 38270582
Purpose: Paracrine activation of pro-fibrotic hedgehog (HH) signaling in pancreatic ductal adenocarcinoma (PDAC) results in stromal amplification that compromises tumor drug delivery, efficacy, and patient survival. Interdiction of HH-mediated tumor-stroma...
6.
McDermott M, Browne B, Conlon N, OBrien N, Slamon D, Henry M, et al.
Mol Cancer
. 2023 Nov;
22(1):175.
PMID: 37915024
No abstract available.
7.
ONeill F, Allen-Coyle T, Roche S, Meiller J, Conlon N, Swan N, et al.
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983764
Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor,...
8.
Smith H, Grant S, Meleady P, Henry M, OGorman D, Clynes M, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613662
Mannan-rich fraction (MRF) isolated from has been studied for its beneficial impact on animal intestinal health. Herein, we examined how MRF affected the formation of reactive oxygen species (ROS), impacting...
9.
Efeoglu E, Henry M, Clynes M, Meleady P
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291610
The development of drug resistance in lung cancer is a major clinical challenge, leading to a 5-year survival rate of only 18%. Therefore, unravelling the mechanisms of drug resistance and...
10.
Allen-Coyle T, Niu J, Welsch E, Conlon N, Garner W, Clynes M, et al.
AAPS J
. 2022 Oct;
24(6):108.
PMID: 36229752
The multi-drug combination regime, FOLFIRINOX, is a standard of care chemotherapeutic therapy for pancreatic cancer patients. However, systematic evaluation of potential pharmacodynamic interactions among multi-drug therapy has not been reported...