Mark W Sleeman
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Explore the profile of Mark W Sleeman including associated specialties, affiliations and a list of published articles.
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53
Citations
2588
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Recent Articles
1.
Su Q, Kim S, Adewale F, Zhou Y, Aldler C, Ni M, et al.
iScience
. 2025 Feb;
28(2):111951.
PMID: 39995867
[This corrects the article DOI: 10.1016/j.isci.2021.103233.].
2.
Zhou Y, Stevis P, Cao J, Ehrlich G, Jones J, Rafique A, et al.
Nat Commun
. 2024 Nov;
15(1):9776.
PMID: 39532904
Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I...
3.
Mohammadi K, Sleeman M, Boyapati A, Bigdelou P, Geba G, Fazio S
J Lipid Res
. 2024 May;
65(6):100568.
PMID: 38795859
Plasma lipid levels are modulated by systemic infection and inflammation; it is unknown whether these changes reflect inflammatory responses or caused directly by pathogen presence. We explored the hypothesis that...
4.
Smagris E, Shihanian L, Mintah I, Bigdelou P, Livson Y, Brown H, et al.
PLoS Genet
. 2024 Mar;
20(3):e1011179.
PMID: 38437227
Recent human genome-wide association studies have identified common missense variants in MARC1, p.Ala165Thr and p.Met187Lys, associated with lower hepatic fat, reduction in liver enzymes and protection from most causes of...
5.
Zhou Y, Zhao Y, Carbonaro M, Chen H, Germino M, Adler C, et al.
Metabolism
. 2024 Mar;
154:155830.
PMID: 38428673
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver zonation. A perivenous-periportal...
6.
Altarejos J, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert A, et al.
Sci Transl Med
. 2023 Nov;
15(723):eadd4897.
PMID: 37992152
Deficiency in the adipose-derived hormone leptin or leptin receptor signaling causes class 3 obesity in individuals with genetic loss-of-function mutations in leptin or its receptor LEPR and metabolic and liver...
7.
Lawler P, Manvelian G, Coppi A, Damask A, Cantor M, Ferreira M, et al.
Crit Care Explor
. 2023 Nov;
5(11):e0997.
PMID: 37954898
Objectives: Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies-lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early inhibition of proprotein convertase...
8.
Adam R, Pryce D, Lee J, Zhao Y, Mintah I, Min S, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(32):e2309967120.
PMID: 37523551
Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E (, activin E) loss-of-function variants are associated with a lower waist-to-hip...
9.
Stec M, Su Q, Adler C, Zhang L, Golann D, Khan N, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2221249120.
PMID: 37410813
Asynchronous skeletal muscle degeneration/regeneration is a hallmark feature of Duchenne muscular dystrophy (DMD); however, traditional -omics technologies that lack spatial context make it difficult to study the biological mechanisms of...
10.
Zhou Y, Stevis P, Cao J, Saotome K, Wu J, Glatman Zaretsky A, et al.
Sci Adv
. 2023 Mar;
9(11):eade4395.
PMID: 36930708
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo-electron microscopy structures...