Mark Maddison
Overview
Explore the profile of Mark Maddison including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
4630
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Recent Articles
1.
Petljak M, Alexandrov L, Brammeld J, Price S, Wedge D, Grossmann S, et al.
Cell
. 2019 Mar;
176(6):1282-1294.e20.
PMID: 30849372
Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity...
2.
Behjati S, Tarpey P, Haase K, Ye H, Young M, Alexandrov L, et al.
Nat Commun
. 2017 Jun;
8:15936.
PMID: 28643781
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing...
3.
Cooper C, Eeles R, Wedge D, Van Loo P, Gundem G, Alexandrov L, et al.
Nat Genet
. 2015 May;
47(6):689.
PMID: 26018901
No abstract available.
4.
Cooper C, Eeles R, Wedge D, Van Loo P, Gundem G, Alexandrov L, et al.
Nat Genet
. 2015 Mar;
47(4):367-372.
PMID: 25730763
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were...
5.
Tubio J, Li Y, Ju Y, Martincorena I, Cooke S, Tojo M, et al.
Science
. 2014 Aug;
345(6196):1251343.
PMID: 25082706
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences...
6.
Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge D, Tamuri A, et al.
Nature
. 2014 Jul;
513(7518):422-425.
PMID: 25043003
The somatic mutations present in the genome of a cell accumulate over the lifetime of a multicellular organism. These mutations can provide insights into the developmental lineage tree, the number...
7.
Meier B, Cooke S, Weiss J, Bailly A, Alexandrov L, Marshall J, et al.
Genome Res
. 2014 Jul;
24(10):1624-36.
PMID: 25030888
Mutation is associated with developmental and hereditary disorders, aging, and cancer. While we understand some mutational processes operative in human disease, most remain mysterious. We used Caenorhabditis elegans whole-genome sequencing...
8.
Li Y, Schwab C, Ryan S, Papaemmanuil E, Robinson H, Jacobs P, et al.
Nature
. 2014 Mar;
508(7494):98-102.
PMID: 24670643
Changes in gene dosage are a major driver of cancer, known to be caused by a finite, but increasingly well annotated, repertoire of mutational mechanisms. This can potentially generate correlated...
9.
Stephens P, Davies H, Mitani Y, Van Loo P, Shlien A, Tarpey P, et al.
J Clin Invest
. 2013 Jun;
123(7):2965-8.
PMID: 23778141
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of...
10.
Tarpey P, Behjati S, Cooke S, Van Loo P, Wedge D, Pillay N, et al.
Nat Genet
. 2013 Jun;
45(8):923-6.
PMID: 23770606
Chondrosarcoma is a heterogeneous collection of malignant bone tumors and is the second most common primary malignancy of bone after osteosarcoma. Recent work has identified frequent, recurrent mutations in IDH1...