Mark G Goebl
Overview
Explore the profile of Mark G Goebl including associated specialties, affiliations and a list of published articles.
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14
Citations
427
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Recent Articles
1.
Adler J, Heller B, Bringman L, Ranahan W, Cocklin R, Goebl M, et al.
J Biol Chem
. 2013 Apr;
288(21):15181-93.
PMID: 23564455
The adaptor protein Amot130 scaffolds components of the Hippo pathway to promote the inhibition of cell growth. This study describes how Amot130 through binding and activating the ubiquitin ligase AIP4/Itch...
2.
Lin L, Wagner M, Cocklin R, Kuzma A, Harrington M, Molitoris B, et al.
Antimicrob Agents Chemother
. 2010 Oct;
55(1):246-54.
PMID: 20956596
Gentamicin is a highly efficacious antibiotic against Gram-negative bacteria. However, its usefulness in treating infections is compromised by its poorly understood renal toxicity. Toxic effects are also seen in a...
3.
Benson E, Goebl M, Yang F, Kapur R, McClintick J, Sanghani S, et al.
Exp Hematol
. 2009 Nov;
38(2):71-81.
PMID: 19941935
Objective: Emerging work has revealed an integral role of the tumor necrosis factor-alpha (TNF-alpha) nuclear factor (NF)-kappaB pathway in the regulation of hematopoiesis. TNF-alpha inhibition of hematopoietic stem/progenitor cell growth...
4.
Radivojac P, Vacic V, Haynes C, Cocklin R, Mohan A, Heyen J, et al.
Proteins
. 2009 Sep;
78(2):365-80.
PMID: 19722269
Ubiquitination plays an important role in many cellular processes and is implicated in many diseases. Experimental identification of ubiquitination sites is challenging due to rapid turnover of ubiquitinated proteins and...
5.
Lockett A, Goebl M, Harrington M
Am J Physiol Cell Physiol
. 2008 Jun;
295(2):C313-23.
PMID: 18562480
The transcription factor NF-kappaB is an essential regulator of the innate immune response that functions as the first line of defense against infections. Activation of the innate immune response by...
6.
Ott L, Resing K, Sizemore A, Heyen J, Cocklin R, Pedrick N, et al.
J Proteome Res
. 2007 May;
6(6):2176-85.
PMID: 17503796
The pro-inflammatory cytokines, Tumor Necrosis Factor-alpha (TNFalpha) and Interleukin-1 (IL-1) mediate the innate immune response. Dysregulation of the innate immune response contributes to the pathogenesis of cancer, arthritis, and congestive...
7.
Luo Y, Kwon H, Montano S, Georgiadis M, Goebl M, Harrington M
Am J Physiol Cell Physiol
. 2006 Nov;
292(3):C1013-23.
PMID: 17079333
Epidemiological data have implicated perturbations in the regulation of NF-kappaB activity to diseases that affect a large number of Americans today. Specifically, chronic activation of genes involved in the inflammatory...
8.
Vig-Varga E, Benson E, Limbil T, Allison B, Goebl M, Harrington M
Gynecol Oncol
. 2006 Apr;
103(1):45-52.
PMID: 16574204
Objective: The intracellular redox state plays an important role in controlling inflammation. Clinical and laboratory data suggest that inflammation can lead to tumor progression. We hypothesized that restoring intracellular redox...
9.
Wagner M, Molnar E, Molitoris B, Goebl M
Antimicrob Agents Chemother
. 2006 Jan;
50(2):587-95.
PMID: 16436714
Gentamicin continues to be a primary antibiotic against gram-negative infections. Unfortunately, associated nephro- and ototoxicity limit its use. Our previous mammalian studies showed that gentamicin is trafficked to the endoplasmic...
10.
Kwon H, Haag Breese E, Vig-Varga E, Luo Y, Lee Y, Goebl M, et al.
Mol Cell Biol
. 2004 Oct;
24(21):9317-26.
PMID: 15485901
A myriad of stimuli including proinflammatory cytokines, viruses, and chemical and mechanical insults activate a kinase complex composed of IkappaB kinase beta (IKK-beta), IKK-alpha, and IKK-gamma/N, leading to changes in...