Mark F van Delft
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Explore the profile of Mark F van Delft including associated specialties, affiliations and a list of published articles.
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25
Citations
3017
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Recent Articles
1.
Li K, Yap Y, Moujalled D, Sumardy F, Khakham Y, Georgiou A, et al.
Sci Adv
. 2025 Mar;
11(10):eadr8146.
PMID: 40043112
Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2-associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent anion...
2.
Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient
Emery-Corbin S, Yousef J, Adhikari S, Sumardy F, Nhu D, van Delft M, et al.
Proteomics
. 2024 May;
24(16):e2300644.
PMID: 38766901
Thermal proteome profiling (TPP) is a powerful tool for drug target deconvolution. Recently, data-independent acquisition mass spectrometry (DIA-MS) approaches have demonstrated significant improvements to depth and missingness in proteome data,...
3.
Yuan Z, van Delft M, Li M, Sumardy F, Smith B, Huang D, et al.
PLoS Biol
. 2024 May;
22(5):e3002617.
PMID: 38696533
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial...
4.
Pierotti C, Jacobsen A, Grohmann C, Dempsey R, Etemadi N, Hildebrand J, et al.
Biochem J
. 2023 Apr;
480(9):665-684.
PMID: 37115711
Necroptosis is a mode of programmed, lytic cell death that is executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following activation by the upstream kinases, receptor-interacting serine/threonine protein kinase...
5.
Huang A, Chin H, Reljic B, Djajawi T, Tan I, Gong J, et al.
Cell Death Differ
. 2022 Sep;
30(3):632-646.
PMID: 36171332
Intrinsic apoptosis is principally governed by the BCL-2 family of proteins, but some non-BCL-2 proteins are also critical to control this process. To identify novel apoptosis regulators, we performed a...
6.
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
Jacobsen A, Pierotti C, Lowes K, Au A, Zhang Y, Etemadi N, et al.
Cell Death Dis
. 2022 Apr;
13(4):291.
PMID: 35365636
Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after its activation by the upstream...
7.
Li K, van Delft M, Dewson G
EMBO J
. 2021 May;
40(14):e107341.
PMID: 34037273
Apoptotic cell death is implicated in both physiological and pathological processes. Since many types of cancerous cells intrinsically evade apoptotic elimination, induction of apoptosis has become an attractive and often...
8.
Fedele P, Liao Y, Gong J, Yao Y, van Delft M, Low M, et al.
Leukemia
. 2020 Nov;
35(7):2114-2118.
PMID: 33149265
No abstract available.
9.
Pierotti C, Tanzer M, Jacobsen A, Hildebrand J, Garnier J, Sharma P, et al.
ACS Chem Biol
. 2020 Sep;
15(10):2702-2713.
PMID: 32902249
Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound is a more potent analogue of the published compound and inhibits necroptosis...
10.
Djajawi T, Liu L, Gong J, Huang A, Luo M, Xu Z, et al.
Cell Death Differ
. 2020 Feb;
27(8):2484-2499.
PMID: 32094511
MCL1, a BCL2 relative, is critical for the survival of many cells. Its turnover is often tightly controlled through both ubiquitin-dependent and -independent mechanisms of proteasomal degradation. Several cell stress...