Mark Eastwood
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Explore the profile of Mark Eastwood including associated specialties, affiliations and a list of published articles.
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846
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Recent Articles
21.
Liu S, Xu S, Kennedy L, Pala D, Chen Y, Eastwood M, et al.
Mol Biol Cell
. 2007 Apr;
18(6):2169-78.
PMID: 17409352
Transforming growth factor beta (TGFbeta) plays a critical role in connective tissue remodeling by fibroblasts during development, tissue repair, and fibrosis. We investigated the molecular pathways in the transmission of...
22.
Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, et al.
Exp Cell Res
. 2007 Jan;
313(5):952-64.
PMID: 17239853
CCN2 is expressed by mesenchymal cells undergoing active tissue remodeling, and is characteristically overexpressed in connective tissue pathologies such as fibrosis and cancer. However, the physiological roles and mechanism of...
23.
Chen Y, Shi-Wen X, Eastwood M, Black C, Denton C, Leask A, et al.
Arthritis Rheum
. 2006 Apr;
54(4):1309-16.
PMID: 16575856
Objective: To use a specific transforming growth factor beta receptor type I (TGFbetaRI; activin receptor-like kinase 5 [ALK-5]) kinase inhibitor (SD208) to determine the role of activation of the TGFbetaRI...
24.
Sarraf C, Harris A, McCulloch A, Eastwood M
Heart Lung Circ
. 2005 Dec;
11(3):142-50.
PMID: 16352087
Cardiovascular diseases are common in ageing communities globally. This fact is most striking in the industrialised world where the aged population makes up a large proportion of society. Elderly patients...
25.
Chen Y, Shi-Wen X, Van Beek J, Kennedy L, McLeod M, Renzoni E, et al.
Am J Pathol
. 2005 Nov;
167(6):1699-711.
PMID: 16314481
Scarring is characterized by excessive synthesis and contraction of extracellular matrix. Here, we show that fibroblasts from scarred (lesional) areas of patients with the chronic fibrotic disorder diffuse scleroderma [diffuse...
26.
Denton C, Lindahl G, Khan K, Shiwen X, Ong V, Gaspar N, et al.
J Biol Chem
. 2005 Feb;
280(16):16053-65.
PMID: 15708853
We have generated transgenic mice expressing a kinase-deficient type II transforming growth factor-beta (TGFbeta) receptor selectively on fibroblasts (TbetaRIIDeltak-fib). These mice develop dermal and pulmonary fibrosis. In the present study...
27.
McCulloch A, Harris A, Sarraf C, Eastwood M
Tissue Eng
. 2004 May;
10(3-4):565-73.
PMID: 15165473
In the present study we have developed a multi-cue bioreactor (MCB) that is capable of delivering a range of stimuli to assist the development of a tissue-engineered construct. The MCB...
28.
Shi-Wen X, Chen Y, Denton C, Eastwood M, Renzoni E, Bou-Gharios G, et al.
Mol Biol Cell
. 2004 Mar;
15(6):2707-19.
PMID: 15047866
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence...
29.
Sethi K, V Yannas I, Mudera V, Eastwood M, McFarland C, Brown R
Wound Repair Regen
. 2002 Nov;
10(6):397-408.
PMID: 12453144
Contraction plays a major role in wound healing and is inevitably mediated through the mechanical interaction of fibroblast cytoskeleton and integrins with their extracellular matrix ligands. Cell-matrix attachment is critical...
30.
Brown R, Sethi K, Gwanmesia I, Raemdonck D, Eastwood M, Mudera V
Exp Cell Res
. 2002 Mar;
274(2):310-22.
PMID: 11900491
Generation of contractile forces as fibroblasts attach and migrate through collagenous substrates is a fundamental behavior, yet its regulation and consequences are obscure. Although the transforming growth factor-betas (TGF-beta) are...