Mark Eastwood
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Explore the profile of Mark Eastwood including associated specialties, affiliations and a list of published articles.
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30
Citations
846
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Recent Articles
11.
Liu S, Xu S, Blumbach K, Eastwood M, Denton C, Eckes B, et al.
J Cell Sci
. 2010 Oct;
123(Pt 21):3674-82.
PMID: 20940256
In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this...
12.
Verjee L, Midwood K, Davidson D, Eastwood M, Nanchahal J
J Cell Physiol
. 2010 May;
224(3):681-90.
PMID: 20432463
The objective was to study Dupuytren's myofibroblast cells in constrained collagen matrices in order to more closely emulate their in vivo environment and, to correlate their contractility with alpha-smooth muscle...
13.
Shi-Wen X, Eastwood M, Stratton R, Denton C, Leask A, Abraham D
Rheumatology (Oxford)
. 2009 Dec;
49(2):259-63.
PMID: 20007285
Objective: The transcription factor peroxisome proliferator-activated receptor (PPAR)-gamma plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR-gamma expression was reduced...
14.
Xu S, Liu S, Eastwood M, Sonnylal S, Denton C, Abraham D, et al.
PLoS One
. 2009 Oct;
4(10):e7438.
PMID: 19823586
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma...
15.
Shi-Wen X, Parapuram S, Pala D, Chen Y, Carter D, Eastwood M, et al.
Arthritis Rheum
. 2009 Jan;
60(1):234-41.
PMID: 19116914
Objective: Fibrosis is believed to occur through normal tissue remodeling failing to terminate. Tissue repair intimately involves the ability of fibroblasts to contract extracellular matrix (ECM), and enhanced ECM contraction...
16.
Leask A, Shi-Wen X, Khan K, Chen Y, Holmes A, Eastwood M, et al.
J Cell Sci
. 2008 Oct;
121(Pt 20):3459-67.
PMID: 18827016
Cutaneous wound repair requires the de novo induction of a specialized form of fibroblast, the alpha-smooth muscle actin (alpha-SMA)-expressing myofibroblast, which migrates into the wound where it adheres to and...
17.
Denton C, Khan K, Hoyles R, Shiwen X, Leoni P, Chen Y, et al.
J Invest Dermatol
. 2008 Jun;
129(1):194-204.
PMID: 18563179
Previous attempts to delete type II TGFbeta receptor (TbetaRII) in fibroblasts have precluded examination of adult mice due to early mortality. We have selectively deleted TbetaRII postnatally in differentiated connective...
18.
Chen Y, Leask A, Abraham D, Pala D, Shiwen X, Khan K, et al.
Arthritis Rheum
. 2008 Feb;
58(2):577-85.
PMID: 18240216
Objective: To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis...
19.
Dynamic protrusive cell behaviour generates force and drives early matrix contraction by fibroblasts
Dahlmann-Noor A, Martin-Martin B, Eastwood M, Khaw P, Bailly M
Exp Cell Res
. 2007 Sep;
313(20):4158-69.
PMID: 17869245
We investigated the cellular mechanisms underlying force generation and matrix contraction, using human corneal, Tenon's and scleral fibroblasts in a standard collagen matrix. We used timelapse light and confocal reflection...
20.
Smith S, Taylor P, Chester A, Allen S, Dreger S, Eastwood M, et al.
J Heart Valve Dis
. 2007 Aug;
16(4):440-6.
PMID: 17702371
Background And Aim Of The Study: Cardiac valves perform highly sophisticated functions that depend upon the specific characteristics of the component interstitial cells (ICs). The ability of valve ICs to...