Mark D Benson
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Explore the profile of Mark D Benson including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tahir U, Barber J, Cruz D, Kars M, Deng S, Tuftin B, et al.
J Clin Invest
. 2024 Sep;
134(21).
PMID: 39316441
BACKGROUNDMost GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODSWe conducted a discovery GWAS of approximately 3,000...
2.
Xiao S, Li V, Lyu X, Chen X, Wei W, Abbasi F, et al.
Nat Metab
. 2024 Mar;
6(4):659-669.
PMID: 38499766
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin's effects on energy balance. Here, we show that...
3.
Xiao S, Li V, Lyu X, Chen X, Wei W, Abbasi F, et al.
bioRxiv
. 2023 Nov;
PMID: 37961394
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. The mechanisms that mediate metformin's effects on energy balance remain incompletely defined. Here we show that metformin is...
4.
Benson M, Eisman A, Tahir U, Katz D, Deng S, Ngo D, et al.
Cell Metab
. 2023 Aug;
35(9):1646-1660.e3.
PMID: 37582364
Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating proteins and metabolites are...
5.
Tanzo J, Li V, Wiggenhorn A, Moya-Garzon M, Wei W, Lyu X, et al.
J Biol Chem
. 2023 Apr;
299(6):104764.
PMID: 37121548
N-acyl amino acids are a large family of circulating lipid metabolites that modulate energy expenditure and fat mass in rodents. However, little is known about the regulation and potential cardiometabolic...
6.
Tanzo J, Li V, Wiggenhorn A, Moya-Garzon M, Wei W, Lyu X, et al.
bioRxiv
. 2023 Mar;
PMID: 36945562
N-acyl amino acids are a large family of circulating lipid metabolites that modulate energy expenditure and fat mass in rodents. However, little is known about the regulation and potential cardiometabolic...
7.
Chen Z, Gao Y, Keyes M, Deng S, Mi M, Farrell L, et al.
Diabetes
. 2023 Jan;
72(4):532-543.
PMID: 36630488
Proteomics has been used to study type 2 diabetes, but the majority of available data are from White participants. Here, we extend prior work by analyzing a large cohort of...
8.
Bersell K, Yang T, Mosley J, Glazer A, Hale A, Kryshtal D, et al.
Circulation
. 2022 Dec;
147(10):824-840.
PMID: 36524479
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We...
9.
Chen Z, Pacheco J, Gao Y, Deng S, Peterson B, Shi X, et al.
Diabetes
. 2022 Aug;
71(11):2426-2437.
PMID: 35998269
Nontargeted metabolomics methods have increased potential to identify new disease biomarkers, but assessments of the additive information provided in large human cohorts by these less biased techniques are limited. To...
10.
Tahir U, Katz D, Avila-Pachecho J, Bick A, Pampana A, Robbins J, et al.
Nat Commun
. 2022 Aug;
13(1):4923.
PMID: 35995766
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to...