Mark A Perrella
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Explore the profile of Mark A Perrella including associated specialties, affiliations and a list of published articles.
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105
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3056
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Recent Articles
1.
Kosmas K, Papathanasiou A, Spyropoulos F, Rehman R, Cunha A, Fredenburgh L, et al.
Cells
. 2024 Nov;
13(21.
PMID: 39513903
The role of stress granules (SGs) in pulmonary arterial hypertension (PAH) is unknown. We hypothesized that SG formation contributes to abnormal vascular phenotypes, and cardiac and skeletal muscle dysfunction in...
2.
Mayers J, Varon J, Zhou R, Daniel-Ivad M, Beaulieu C, Bhosle A, et al.
Cell
. 2024 Jun;
187(15):4095-4112.e21.
PMID: 38885650
The growth of antimicrobial resistance (AMR) highlights an urgent need to identify bacterial pathogenic functions that may be targets for clinical intervention. Although severe infections profoundly alter host metabolism, prior...
3.
Hwang N, Ghanta S, Li Q, Lamattina A, Murzin E, Lederer J, et al.
Mol Ther
. 2024 May;
32(7):2232-2247.
PMID: 38734903
Sepsis is a life-threatening process due to organ dysfunction resulting from severe infections. Mesenchymal stromal cells (MSCs) are being investigated as therapy for sepsis, along with conditioning regimens to improve...
4.
Li Q, Lin J, Luo S, Schmitz-Abe K, Agrawal R, Meng M, et al.
J Cachexia Sarcopenia Muscle
. 2024 May;
15(3):1003-1015.
PMID: 38725372
Background: Autosomal-recessive mutations in SPEG (striated muscle preferentially expressed protein kinase) have been linked to centronuclear myopathy with or without dilated cardiomyopathy (CNM5). Loss of SPEG is associated with defective...
5.
Liu T, Liu S, Rui X, Cao Y, Hecker J, Guo F, et al.
Eur Respir J
. 2024 Mar;
63(5).
PMID: 38514093
Rationale: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of interferon-stimulated genes (). How asthma-susceptibility genes modulate cellular response upon viral infection by fine-tuning...
6.
Spyropoulos F, Das A, Waldeck-Weiermair M, Yadav S, Pandey A, Guo R, et al.
J Clin Invest
. 2024 Mar;
134(9).
PMID: 38483521
No abstract available.
7.
Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, et al.
Basic Res Cardiol
. 2023 Dec;
119(1):151-168.
PMID: 38145999
A deficiency of striated preferentially expressed gene (Speg), a member of the myosin light chain kinase family, results in abnormal myofibril structure and function of immature cardiomyocytes (CMs), corresponding with...
8.
Ng J, Marneth A, Griffith A, Younger D, Ghanta S, Jiao A, et al.
J Innate Immun
. 2023 Oct;
15(1):765-781.
PMID: 37797588
Novel therapeutics are urgently needed to prevent opportunistic infections in immunocompromised individuals undergoing cancer treatments or other immune-suppressive therapies. Trained immunity is a promising strategy to reduce this burden of...
9.
Mayers J, Varon J, Zhou R, Daniel-Ivad M, Beaulieu C, Bholse A, et al.
bioRxiv
. 2023 Oct;
PMID: 37790300
The growth of antimicrobial resistance (AMR) has highlighted an urgent need to identify bacterial pathogenic functions that may be targets for clinical intervention. Although severe bacterial infections profoundly alter host...
10.
Li Q, Lin J, Luo S, Schmitz-Abe K, Agrawal R, Meng M, et al.
bioRxiv
. 2023 May;
PMID: 37162921
Synopsis: We have previously linked mutations in (striated preferentially expressed protein) with a recessive form of centronuclear myopathy and/or dilated cardiomyopathy and have characterized a striated muscle-specific SPEG-deficient mouse model...