Mariano F Zacarias-Fluck
Overview
Explore the profile of Mariano F Zacarias-Fluck including associated specialties, affiliations and a list of published articles.
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6
Citations
150
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Recent Articles
1.
Zacarias-Fluck M, Soucek L, Whitfield J
Front Cell Dev Biol
. 2024 Mar;
12:1342872.
PMID: 38510176
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation,...
2.
Zacarias-Fluck M, Masso-Valles D, Giuntini F, Gonzalez-Larreategui I, Kaur J, Casacuberta-Serra S, et al.
Genes Dev
. 2023 Apr;
37(7-8):303-320.
PMID: 37024284
MYC's key role in oncogenesis and tumor progression has long been established for most human cancers. In melanoma, its deregulated activity by amplification of 8q24 chromosome or by upstream signaling...
3.
Masso-Valles D, Beaulieu M, Jauset T, Giuntini F, Zacarias-Fluck M, Foradada L, et al.
Cancer Res Commun
. 2023 Mar;
2(2):110-130.
PMID: 36860495
Significance: While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts...
4.
Zacarias-Fluck M, Jauset T, Martinez-Martin S, Kaur J, Casacuberta-Serra S, Masso-Valles D, et al.
Life Sci Alliance
. 2021 Mar;
4(5).
PMID: 33653688
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the...
5.
Beaulieu M, Jauset T, Masso-Valles D, Martinez-Martin S, Rahl P, Maltais L, et al.
Sci Transl Med
. 2019 Mar;
11(484).
PMID: 30894502
Inhibiting MYC has long been considered unfeasible, although its key role in human cancers makes it a desirable target for therapeutic intervention. One reason for its perceived undruggability was the...
6.
Zacarias-Fluck M, Morancho B, Vicario R, Luque Garcia A, Escorihuela M, Villanueva J, et al.
J Natl Cancer Inst
. 2015 May;
107(5).
PMID: 25972601
Background: Oncogene-induced senescence (OIS) is a tumor suppressor mechanism. However, senescent cells remain viable and display a distinct secretome (also known as senescence-associated secretory phenotype [SASP] or senescence messaging secretome,...