Mariana Santa-Marta
Overview
Explore the profile of Mariana Santa-Marta including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
393
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Recent Articles
1.
Perdigao P, Cunha-Santos C, Barbas 3rd C, Santa-Marta M, Goncalves J
Mol Ther Methods Clin Dev
. 2020 Jul;
18:145-158.
PMID: 32637446
Despite efforts to develop effective treatments for eradicating HIV-1, a cure has not yet been achieved. Whereas antiretroviral drugs target an actively replicating virus, latent, nonreplicative forms persist during treatment....
2.
Letra-Vilela R, Cardoso B, Silva-Almeida C, Rocha A, Murtinheira F, Branco-Santos J, et al.
FASEB Bioadv
. 2020 Mar;
2(2):116-125.
PMID: 32123861
Signal transducer and activator of transcription 3 (STAT3) is a ubiquitous and pleiotropic transcription factor that plays essential roles in normal development, immunity, response to tissue damage and cancer. We...
3.
Amaral A, Andrade J, Foxall R, Matoso P, Matos A, S Soares R, et al.
EMBO J
. 2016 Dec;
36(3):346-360.
PMID: 27993935
Cell activation is a vital step for T-cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next-generation sequencing to profile...
4.
Letra-Vilela R, Sanchez-Sanchez A, Rocha A, Martin V, Branco-Santos J, Puente-Moncada N, et al.
Mol Cell Endocrinol
. 2016 Jul;
434:238-49.
PMID: 27402602
Melatonin (N-acetyl-5-methoxytryptamine) is a highly pleiotropic hormone with antioxidant, antiproliferative, oncolytic and neuroprotective properties. Here, we present evidence that the N-acetyl side chain plays a key role in melatonin's antiproliferative...
5.
Perdigao P, Gaj T, Santa-Marta M, Barbas 3rd C, Goncalves J
PLoS One
. 2016 Mar;
11(3):e0150037.
PMID: 26933881
The presence of replication-competent HIV-1 -which resides mainly in resting CD4+ T cells--is a major hurdle to its eradication. While pharmacological approaches have been useful for inducing the expression of...
6.
Santa-Marta M, de Brito P, Godinho-Santos A, Goncalves J
Front Immunol
. 2013 Oct;
4:343.
PMID: 24167505
HIV and human defense mechanisms have co-evolved to counteract each other. In the process of infection, HIV takes advantage of cellular machinery and blocks the action of the host restriction...
7.
Santa-Marta M, Aires da Silva F, Fonseca A, Rato S, Goncalves J
Mol Immunol
. 2006 Apr;
44(4):583-90.
PMID: 16580072
HIV-1 Vif protein protects viral replication in non-permissive cells by inducing degradation of APOBEC3G via ubiquitination and proteasomal pathway, although new studies indicate a putative role in Vif's direct inhibition...
8.
Ribeiro A, Maia E Silva A, Santa-Marta M, Pombo A, Moniz-Pereira J, Goncalves J, et al.
J Virol
. 2004 Dec;
79(2):823-33.
PMID: 15613310
Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in...
9.
Santa-Marta M, Aires da Silva F, Fonseca A, Goncalves J
J Biol Chem
. 2004 Dec;
280(10):8765-75.
PMID: 15611076
The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G), also known as CEM-15, is a host-cell factor involved in innate resistance to retroviral infection. HIV-1 viral infectivity factor (Vif)...
10.
Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D
Genes Dev
. 2004 Dec;
18(23):2861-6.
PMID: 15574592
HIV-1 Vif (viral infectivity factor) protein overcomes the antiviral activity of the DNA deaminase APOBEC3G by targeting it for proteasomal degradation. We report here that Vif targets APOBEC3G for degradation...