Reactive Sulfur and Selenium Species in the Regulation of Bone Homeostasis

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 2022 Aug 8

PMID 35940516

Authors

Annie K Gilbert

Turner D Newton

Marian H Hettiaratchi

Michael D Pluth

Affiliations

Soon will be listed here.

Abstract

Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved in ROS signaling, and recent work suggests RSS and RSeS involvement in the regulation of bone homeostasis. For example, RSS can promote osteogenic differentiation and decrease osteoclast activity and differentiation, and the antioxidant activity of RSeS play crucial roles in balancing bone remodeling. Here, we outline current research progress on the application of RSS and RSeS in bone disease and regeneration. Focusing on these investigations, we highlight different methods, tools, and sources of RSS and RSeS, and we also highlight future opportunities for delivery of RSS and RSeS in biological environments relating to bone.

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