Maria Letizia Barreca
Overview
Explore the profile of Maria Letizia Barreca including associated specialties, affiliations and a list of published articles.
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94
Citations
862
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Recent Articles
1.
Astolfi A, Cernicchi G, Primavera E, Rocchi M, Manfroni G, Sabatini S, et al.
ChemMedChem
. 2025 Jan;
:e202400927.
PMID: 39843395
In this study, we analyzed publicly accessible data related to the Staphylococcus aureus NorA protein, a well-known efflux pump involved in antimicrobial resistance. Our analysis revealed several inconsistencies in data...
2.
Felicetti T, Di Iacovo N, Della Fazia M, Piobbico D, Pieroni S, Pacetti M, et al.
RSC Med Chem
. 2024 Oct;
PMID: 39399313
MicroRNAs (miRNAs) play a crucial role in ovarian cancer (OC) pathogenesis and miRNA processing can be the object of pharmacological intervention. By exploiting our in-house quinolone library, we combined a...
3.
Cernicchi G, Rampacci E, Massari S, Manfroni G, Letizia Barreca M, Tabarrini O, et al.
Arch Pharm (Weinheim)
. 2024 Jun;
357(10):e2400296.
PMID: 38923553
Nontuberculous mycobacteria (NTM), which include the Mycobacterium avium complex, are classified as difficult-to-treat pathogens due to their ability to quickly develop drug resistance against the most common antibiotics used to...
4.
Palazzotti D, Sguilla M, Manfroni G, Cecchetti V, Astolfi A, Letizia Barreca M
Pharmaceuticals (Basel)
. 2024 May;
17(5).
PMID: 38794231
Small molecules that specifically target viral polymerases-crucial enzymes governing viral genome transcription and replication-play a pivotal role in combating viral infections. Presently, approved polymerase inhibitors cover nine human viruses, spanning...
5.
Salvadori L, Paiella M, Castiglioni B, Belladonna M, Manenti T, Ercolani C, et al.
Biomed Pharmacother
. 2024 Apr;
174:116517.
PMID: 38574619
Age-associated osteosarcopenia is an unresolved syndrome characterized by the concomitant loss of bone (osteopenia) and skeletal muscle (sarcopenia) tissues increasing falls, immobility, morbidity, and mortality. Unbalanced resorption of bone in...
6.
Pacetti M, Pismataro M, Felicetti T, Giammarino F, Bonomini A, Tiecco M, et al.
Org Biomol Chem
. 2024 Jan;
22(4):767-783.
PMID: 38167738
Among the eight different triazolopyrimidine isomers existing in nature, 1,2,4-triazolo[1,5-]pyrimidine (TZP) is one of the most studied and used isomers in medicinal chemistry. For some years, our group has been...
7.
Palazzotti D, Felicetti T, Sabatini S, Moro S, Letizia Barreca M, Sturlese M, et al.
J Chem Inf Model
. 2023 Jul;
63(15):4875-4887.
PMID: 37515548
The superbug () exhibits several resistance mechanisms, including efflux pumps, that strongly contribute to antimicrobial resistance. In particular, the NorA efflux pump activity is associated with resistance to fluoroquinolone antibiotics...
8.
Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein
Primavera E, Palazzotti D, Letizia Barreca M, Astolfi A
Pharmaceuticals (Basel)
. 2023 Jul;
16(7).
PMID: 37513905
AKT (also known as PKB) is a serine/threonine kinase that plays a pivotal regulatory role in the PI3K/AKT/mTOR signaling pathway. Dysregulation of AKT activity, especially its hyperactivation, is closely associated...
9.
Marsili G, Acchioni C, Remoli A, Amatore D, Sgarbanti R, De Angelis M, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445672
There is an urgent need to identify efficient antiviral compounds to combat existing and emerging RNA virus infections, particularly those related to seasonal and pandemic influenza outbreaks. While inhibitors of...
10.
Pismataro M, Astolfi A, Letizia Barreca M, Pacetti M, Schenone S, Bandiera T, et al.
J Med Chem
. 2023 May;
66(10):6498-6522.
PMID: 37134182
Synthetic lethality (SL) is an innovative strategy in targeted anticancer therapy that exploits tumor genetic vulnerabilities. This topic has come to the forefront in recent years, as witnessed by the...