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Giuseppe Manfroni

Explore the profile of Giuseppe Manfroni including associated specialties, affiliations and a list of published articles. Areas
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Articles 75
Citations 653
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Recent Articles
1.
Astolfi A, Cernicchi G, Primavera E, Rocchi M, Manfroni G, Sabatini S, et al.
ChemMedChem . 2025 Jan; :e202400927. PMID: 39843395
In this study, we analyzed publicly accessible data related to the Staphylococcus aureus NorA protein, a well-known efflux pump involved in antimicrobial resistance. Our analysis revealed several inconsistencies in data...
2.
Felicetti T, Di Iacovo N, Della Fazia M, Piobbico D, Pieroni S, Pacetti M, et al.
RSC Med Chem . 2024 Oct; PMID: 39399313
MicroRNAs (miRNAs) play a crucial role in ovarian cancer (OC) pathogenesis and miRNA processing can be the object of pharmacological intervention. By exploiting our in-house quinolone library, we combined a...
3.
Felicetti T, Sarnari C, Gaito R, Tabarrini O, Manfroni G
J Med Chem . 2024 Jul; 67(14):11543-11579. PMID: 38970494
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization globally, ranking second only to malaria in terms of infant mortality. Although three vaccines have recently been approved...
4.
Cernicchi G, Rampacci E, Massari S, Manfroni G, Letizia Barreca M, Tabarrini O, et al.
Arch Pharm (Weinheim) . 2024 Jun; 357(10):e2400296. PMID: 38923553
Nontuberculous mycobacteria (NTM), which include the Mycobacterium avium complex, are classified as difficult-to-treat pathogens due to their ability to quickly develop drug resistance against the most common antibiotics used to...
5.
Palazzotti D, Sguilla M, Manfroni G, Cecchetti V, Astolfi A, Letizia Barreca M
Pharmaceuticals (Basel) . 2024 May; 17(5). PMID: 38794231
Small molecules that specifically target viral polymerases-crucial enzymes governing viral genome transcription and replication-play a pivotal role in combating viral infections. Presently, approved polymerase inhibitors cover nine human viruses, spanning...
6.
Ghiandoni G, Flanagan S, Bodkin M, Nizi M, Galera-Prat A, Brai A, et al.
Mol Inform . 2024 Jan; 43(4):e202300183. PMID: 38258328
De novo design has been a hotly pursued topic for many years. Most recent developments have involved the use of deep learning methods for generative molecular design. Despite increasing levels...
7.
Acchioni C, Acchioni M, Mancini F, Amendola A, Marsili G, Tirelli V, et al.
Virology . 2023 Apr; 583:1-13. PMID: 37060797
Type I interferon (IFN-I) evasion by Dengue virus (DENV) is key in DENV pathogenesis. The non-structural protein 5 (NS5) antagonizes IFN-I response through the degradation of the signal transducer and...
8.
Iorio C, Manfroni G
Future Med Chem . 2023 Mar; 15(5):399-403. PMID: 36999380
No abstract available.
9.
Felicetti T, Gwee C, Burali M, Chan K, Alonso S, Pismataro M, et al.
Eur J Med Chem . 2023 Mar; 252:115283. PMID: 36965228
Dengue virus (DENV), a mosquito-borne flavivirus, continues to be a major public health threat in many countries and no approved antiviral therapeutics are available yet. In this work, we designed...
10.
Felicetti T, Cedraro N, Astolfi A, Cernicchi G, Mangiaterra G, Vaiasicca S, et al.
Eur J Med Chem . 2022 Aug; 241:114656. PMID: 35963131
Antimicrobial resistance (AMR) represents a global health issue threatening our social lifestyle and the world economy. Efflux pumps are widely involved in AMR by playing a primary role in the...