Maria Kleppe
Overview
Explore the profile of Maria Kleppe including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
2585
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Recent Articles
11.
Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao-Shen H, et al.
J Clin Invest
. 2019 Feb;
129(4):1596-1611.
PMID: 30730307
Constitutive JAK2 signaling is central to myeloproliferative neoplasm (MPN) pathogenesis and results in activation of STAT, PI3K/AKT, and MEK/ERK signaling. However, the therapeutic efficacy of current JAK2 inhibitors is limited....
12.
Comen E, Bowman R, Kleppe M
Front Cell Dev Biol
. 2018 Jun;
6:56.
PMID: 29946544
Historically, the link between chronic inflammation and cancer has long been speculated. Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point to the role of...
13.
Kleppe M, Koche R, Zou L, van Galen P, Hill C, Dong L, et al.
Cancer Cell
. 2018 Apr;
33(4):785-787.
PMID: 29634952
No abstract available.
14.
Kleppe M, Spitzer M, Li S, Hill C, Dong L, Papalexi E, et al.
Cell Stem Cell
. 2018 Feb;
22(2):277.
PMID: 29395057
No abstract available.
15.
Fang J, Muto T, Kleppe M, Bolanos L, Hueneman K, Walker C, et al.
Cell Rep
. 2018 Feb;
22(5):1250-1262.
PMID: 29386112
Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well...
16.
Kleppe M, Koche R, Zou L, van Galen P, Hill C, Dong L, et al.
Cancer Cell
. 2017 Dec;
33(1):29-43.e7.
PMID: 29249691
Genetic and functional studies underscore the central role of JAK/STAT signaling in myeloproliferative neoplasms (MPNs). However, the mechanisms that mediate transformation in MPNs are not fully delineated, and clinically utilized...
17.
Hobbs G, Hanasoge Somasundara A, Kleppe M, Litvin R, Arcila M, Ahn J, et al.
Haematologica
. 2017 Oct;
103(1):e5-e9.
PMID: 29051283
No abstract available.
18.
Kleppe M, Spitzer M, Li S, Hill C, Dong L, Papalexi E, et al.
Cell Stem Cell
. 2017 Oct;
21(4):489-501.e7.
PMID: 28965767
JAK1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in immune function, while abnormal JAK1 activity has been linked to immunological and neoplastic diseases. Specific functions...
19.
Kleppe M, Comen E, Wen H, Bastian L, Blum B, Rapaport F, et al.
NPJ Breast Cancer
. 2017 Jul;
1:15005.
PMID: 28721364
Background: Malignant transformation requires the interaction of cancer cells with their microenvironment, including infiltrating leukocytes. However, somatic mutational studies have focused on alterations in cancer cells, assuming that the microenvironment...
20.
Poulos M, Ramalingam P, Gutkin M, Kleppe M, Ginsberg M, Crowley M, et al.
Nat Commun
. 2016 Dec;
7:13829.
PMID: 28000664
Haematopoietic stem cells (HSCs) reside in distinct niches within the bone marrow (BM) microenvironment, comprised of endothelial cells (ECs) and tightly associated perivascular constituents that regulate haematopoiesis through the expression...