Maria A Leo
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Explore the profile of Maria A Leo including associated specialties, affiliations and a list of published articles.
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14
Citations
413
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Recent Articles
1.
Lieber C, Leo M, Cao Q, Mak K, Ren C, Ponomarenko A, et al.
Nutr Res
. 2008 Sep;
27(9):565-573.
PMID: 18769506
In the pathogenesis of non-alcoholic steatohepatitis (NASH), oxidative stress resulting from free radicals generated by cytochrome P4502E1 (CYP2E1) plays a major role suggesting the importance of antioxidants. The objective of...
2.
Lieber C, Leo M, Wang X, Decarli L
Biochem Biophys Res Commun
. 2008 Mar;
370(1):44-8.
PMID: 18342626
The nuclear genes, NAD-dependent deacetylase Sirtuis 1 (SIRT1) and the peroxisome proliferator-activated receptor-gamma coactivator1alpha (PGC-1alpha) are regulators of energy metabolism. Here, we studied the role of alcohol consumption in expression...
3.
Lieber C, Decarli L, Leo M, Mak K, Ponomarenko A, Ren C, et al.
J Hepatol
. 2007 Dec;
48(2):318-26.
PMID: 18093684
Background/aims: Replacing long-chain triacylglycerols (LCT) with medium-chain triacylglycerols (MCT) reduces alcohol-induced liver injury. Because of the similarity of the pathogenesis of alcohol-induced liver damage and non-alcoholic steatohepatitis (NASH), our aim...
4.
Neuman M, Sha K, Esguerra R, Zakhari S, Winkler R, Hilzenrat N, et al.
Dig Dis Sci
. 2007 Nov;
53(6):1468-87.
PMID: 17994278
Hepatitis C viral infection (HCV) results in liver damage leading to inflammation and fibrosis of the liver and increasing rates of hepatic decompensation and hepatocellular carcinoma (HCC). However, the host's...
5.
Lieber C, Cao Q, Decarli L, Leo M, Mak K, Ponomarenko A, et al.
Alcohol Clin Exp Res
. 2007 Aug;
31(10):1660-8.
PMID: 17681033
Background: Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading to lipid peroxidation, mitochondrial dysfunction and hepatotoxicity. We showed that replacement of dietary long-chain triglycerides (LCT) by...
6.
Xu Y, Leo M, Lieber C
Alcohol Alcohol
. 2005 Mar;
40(3):172-5.
PMID: 15753073
Aims: Alcoholic liver injury was shown to result largely from oxidative stress generated by ethanol metabolism via cytochrome P4502E1 (CYP2E1). Our aim was to determine whether this could be overcome...
7.
Lieber C, Leo M, Mak K, Xu Y, Cao Q, Ren C, et al.
Am J Clin Nutr
. 2004 Feb;
79(3):502-9.
PMID: 14985228
Background: Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model. Objective: Our objective was to create...
8.
Lieber C, Leo M, Mak K, Xu Y, Cao Q, Ren C, et al.
Biochem Biophys Res Commun
. 2004 Feb;
315(3):699-703.
PMID: 14975757
The alpha-glucosidase inhibitor acarbose is beneficial in the prevention of type 2 diabetes. To determine whether it attenuates the commonly associated non-alcoholic steatohepatitis (NASH), we used an experimental NASH model....
9.
Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver
Seth D, Leo M, McGuinness P, Lieber C, Brennan Y, Williams R, et al.
Am J Pathol
. 2003 Nov;
163(6):2303-17.
PMID: 14633604
The molecular pathogenesis of alcoholic liver disease (ALD) is not well understood. Gene expression profiling has the potential to identify new pathways and altered molecules in ALD. Gene expression profiles...
10.
Lieber C, Leo M, Cao Q, Ren C, Decarli L
J Clin Gastroenterol
. 2003 Sep;
37(4):336-9.
PMID: 14506392
Unlabelled: GOAL/BACKGROUND: Hepatoprotective effects of silymarin in patients with alcoholic liver disease are controversial. For strict control, this was assessed in non-human primates. STUDY Twelve baboons were fed alcohol with...