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Chaoling Ren

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Recent Articles
1.
Lieber C, Leo M, Cao Q, Mak K, Ren C, Ponomarenko A, et al.
Nutr Res . 2008 Sep; 27(9):565-573. PMID: 18769506
In the pathogenesis of non-alcoholic steatohepatitis (NASH), oxidative stress resulting from free radicals generated by cytochrome P4502E1 (CYP2E1) plays a major role suggesting the importance of antioxidants. The objective of...
2.
Mak K, Ren C, Ponomarenko A, Cao Q, Lieber C
Alcohol Clin Exp Res . 2008 Mar; 32(4):683-9. PMID: 18341646
Background: Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that coats cytoplasmic lipid droplets. The present study evaluated whether alcohol feeding enhances ADRP expression and whether ADRP is a...
3.
Lieber C, Decarli L, Leo M, Mak K, Ponomarenko A, Ren C, et al.
J Hepatol . 2007 Dec; 48(2):318-26. PMID: 18093684
Background/aims: Replacing long-chain triacylglycerols (LCT) with medium-chain triacylglycerols (MCT) reduces alcohol-induced liver injury. Because of the similarity of the pathogenesis of alcohol-induced liver damage and non-alcoholic steatohepatitis (NASH), our aim...
4.
Lieber C, Cao Q, Decarli L, Leo M, Mak K, Ponomarenko A, et al.
Alcohol Clin Exp Res . 2007 Aug; 31(10):1660-8. PMID: 17681033
Background: Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading to lipid peroxidation, mitochondrial dysfunction and hepatotoxicity. We showed that replacement of dietary long-chain triglycerides (LCT) by...
5.
Lieber C, Leo M, Mak K, Xu Y, Cao Q, Ren C, et al.
Am J Clin Nutr . 2004 Feb; 79(3):502-9. PMID: 14985228
Background: Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model. Objective: Our objective was to create...
6.
Lieber C, Leo M, Mak K, Xu Y, Cao Q, Ren C, et al.
Biochem Biophys Res Commun . 2004 Feb; 315(3):699-703. PMID: 14975757
The alpha-glucosidase inhibitor acarbose is beneficial in the prevention of type 2 diabetes. To determine whether it attenuates the commonly associated non-alcoholic steatohepatitis (NASH), we used an experimental NASH model....
7.
Cao Q, Mak K, Ren C, Lieber C
J Biol Chem . 2003 Nov; 279(6):4292-304. PMID: 14625304
Leptin is recognized as a profibrogenic hormone in the liver, but the mechanisms involved have not been clarified. The tissue inhibitor of metalloproteinase (TIMP)-1, which acts through inhibition of collagen...
8.
Lieber C, Leo M, Cao Q, Ren C, Decarli L
J Clin Gastroenterol . 2003 Sep; 37(4):336-9. PMID: 14506392
Unlabelled: GOAL/BACKGROUND: Hepatoprotective effects of silymarin in patients with alcoholic liver disease are controversial. For strict control, this was assessed in non-human primates. STUDY Twelve baboons were fed alcohol with...
9.
Mak K, Wen K, Ren C, Lieber C
Alcohol Clin Exp Res . 2003 Jun; 27(6):997-1005. PMID: 12824822
Background: Polyenylphosphatidylcholine (PPC), a mixture of polyunsaturated phosphatidylcholines extracted from soybeans, attenuates hepatocyte apoptosis induced by ethanol feeding of rats. Our aims were to evaluate whether dilinoleoylphosphatidylcholine (DLPC), the main...
10.
Ren C, Paronetto F, Mak K, Leo M, Lieber C
J Hepatol . 2003 May; 38(6):770-5. PMID: 12763370
Background/aims: Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis....