Maria A Christophorou
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Explore the profile of Maria A Christophorou including associated specialties, affiliations and a list of published articles.
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13
Citations
998
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Recent Articles
1.
Grinat J, Shriever N, Christophorou M
J Cell Sci
. 2024 Dec;
137(24).
PMID: 39704565
Animal genomes are packaged into chromatin, a highly dynamic macromolecular structure of DNA and histone proteins organised into nucleosomes. This accommodates packaging of lengthy genomic sequences within the physical confines...
2.
Bertran M, Walmsley R, Cummings T, Aramburu I, Benton D, Mora Molina R, et al.
Nat Commun
. 2024 Nov;
15(1):9746.
PMID: 39528459
Peptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. PADI4 additionally mediates immune responses and cellular reprogramming, although the full extent of...
3.
Rebak A, Hendriks I, Elsborg J, Buch-Larsen S, Nielsen C, Terslev L, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(6):977-995.
PMID: 38321148
Despite the importance of citrullination in physiology and disease, global identification of citrullinated proteins, and the precise targeted sites, has remained challenging. Here we employed quantitative-mass-spectrometry-based proteomics to generate a...
4.
Singh A, Khan S, Moore D, Andrews S, Christophorou M
Philos Trans R Soc Lond B Biol Sci
. 2023 Oct;
378(1890):20220236.
PMID: 37778387
During mammalian embryo development, pluripotent epiblast cells diversify into the three primary germ layers, which will later give rise to all fetal and adult tissues. These processes involve profound transcriptional...
5.
Christophorou M, Sharma P, Zhang X
Philos Trans R Soc Lond B Biol Sci
. 2023 Oct;
378(1890):20220235.
PMID: 37778381
No abstract available.
6.
Christophorou M
R Soc Open Sci
. 2022 Jun;
9(6):220125.
PMID: 35706669
The post-translational modification of proteins expands the regulatory scope of the proteome far beyond what is achievable through genome regulation. The field of protein citrullination has seen significant progress in...
7.
Young C, Russell J, van de Lagemaat L, Lawson H, Mapperley C, Kranc K, et al.
Biol Open
. 2022 May;
11(6).
PMID: 35603697
Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined. The nuclear deiminase PADI4 regulates pluripotency in the mammalian pre-implantation...
8.
Cummings T, Gori K, Sanchez-Pulido L, Gavriilidis G, Moi D, Wilson A, et al.
Mol Biol Evol
. 2021 Nov;
39(2).
PMID: 34730808
Protein posttranslational modifications add great sophistication to biological systems. Citrullination, a key regulatory mechanism in human physiology and pathophysiology, is enigmatic from an evolutionary perspective. Although the citrullinating enzymes peptidylarginine...
9.
Casanova V, Sousa F, Shakamuri P, Svoboda P, Buch C, DAcremont M, et al.
Front Immunol
. 2020 Mar;
11:85.
PMID: 32117246
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia...
10.
Wiese M, Bannister A, Basu S, Boucher W, Wohlfahrt K, Christophorou M, et al.
Epigenetics Chromatin
. 2019 Apr;
12(1):21.
PMID: 30940194
Background: Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone...