Michael L Nielsen
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Explore the profile of Michael L Nielsen including associated specialties, affiliations and a list of published articles.
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111
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7898
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Recent Articles
1.
Kar P, Chatrin C, dukic N, Suyari O, Schuller M, Zhu K, et al.
EMBO J
. 2024 Sep;
43(21):5327.
PMID: 39322761
No abstract available.
2.
Selles-Baiget S, Ambjorn S, Carli A, Hendriks I, Gallina I, Davey N, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(2):300-314.
PMID: 39300172
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate...
3.
Fabian Z, Kakulidis E, Hendriks I, Kuhbacher U, Larsen N, Oliva-Santiago M, et al.
Nat Commun
. 2024 Aug;
15(1):6641.
PMID: 39103378
DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are...
4.
Coulson-Gilmer C, Littler S, Barnes B, Brady R, Anagho H, Pillay N, et al.
NAR Cancer
. 2024 Jul;
6(3):zcae030.
PMID: 39015544
A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be...
5.
Condezo Y, Sainz-Urruela R, Gomez-H L, Salas-Lloret D, Felipe-Medina N, Bradley R, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(25):e2320995121.
PMID: 38865271
Meiosis, a reductional cell division, relies on precise initiation, maturation, and resolution of crossovers (COs) during prophase I to ensure the accurate segregation of homologous chromosomes during metaphase I. This...
6.
Kar P, Chatrin C, dukic N, Suyari O, Schuller M, Zhu K, et al.
EMBO J
. 2024 Jun;
43(14):2929-2953.
PMID: 38834853
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods. Here, we utilised an...
7.
Carabias A, Camara-Wilpert S, Mestre M, Lopez-Mendez B, Hendriks I, Zhao R, et al.
Mol Cell
. 2024 May;
84(11):2185-2202.e12.
PMID: 38788717
Retrons are toxin-antitoxin systems protecting bacteria against bacteriophages via abortive infection. The Retron-Eco1 antitoxin is formed by a reverse transcriptase (RT) and a non-coding RNA (ncRNA)/multi-copy single-stranded DNA (msDNA) hybrid...
8.
Balachandra V, Shrestha R, Hammond C, Lin S, Hendriks I, Sethi S, et al.
EMBO J
. 2024 Apr;
43(11):2166-2197.
PMID: 38600242
The centromeric histone H3 variant CENP-A is overexpressed in many cancers. The mislocalization of CENP-A to noncentromeric regions contributes to chromosomal instability (CIN), a hallmark of cancer. However, pathways that...
9.
Rebak A, Hendriks I, Elsborg J, Buch-Larsen S, Nielsen C, Terslev L, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(6):977-995.
PMID: 38321148
Despite the importance of citrullination in physiology and disease, global identification of citrullinated proteins, and the precise targeted sites, has remained challenging. Here we employed quantitative-mass-spectrometry-based proteomics to generate a...
10.
Colding-Christensen C, Kakulidis E, Arroyo-Gomez J, Hendriks I, Arkinson C, Fabian Z, et al.
Nat Commun
. 2023 Dec;
14(1):8293.
PMID: 38097601
Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation. Here, we describe UBIMAX (UBiquitin target...