Margarita Schlackow
Overview
Explore the profile of Margarita Schlackow including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
427
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Recent Articles
1.
Di Fazio A, Schlackow M, Pong S, Alagia A, Gullerova M
Nucleic Acids Res
. 2022 Jan;
50(3):1734-1752.
PMID: 35048990
In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves...
2.
Griesbach E, Schlackow M, Marzluff W, Proudfoot N
Nat Commun
. 2021 Jan;
12(1):359.
PMID: 33441544
Phosphorylated H2A.X is a critical chromatin marker of DNA damage repair (DDR) in higher eukaryotes. However, H2A.X gene expression remains relatively uncharacterised. Replication-dependent (RD) histone genes generate poly(A)- mRNA encoding...
3.
Bogucka K, Marini F, Rosigkeit S, Schloeder J, Jonuleit H, David K, et al.
Cancer Gene Ther
. 2020 Nov;
28(5):543.
PMID: 33168935
No abstract available.
4.
Bogucka K, Marini F, Rosigkeit S, Schloeder J, Jonuleit H, David K, et al.
Cancer Gene Ther
. 2020 Oct;
28(5):359-374.
PMID: 33070159
KRAS is one of the most frequently mutated oncogenes, especially in lung cancers. Targeting of KRAS directly or the downstream effector signaling machinery is of prime interest in treating lung...
5.
Burger K, Schlackow M, Gullerova M
Nucleic Acids Res
. 2019 Jan;
47(7):3467-3484.
PMID: 30668775
DNA is constantly exposed to endogenous and exogenous damage. Various types of DNA repair counteract highly toxic DNA double-strand breaks (DSBs) to maintain genome stability. Recent findings suggest that the...
6.
Volanakis A, Kamieniarz-Gdula K, Schlackow M, Proudfoot N
Genes Dev
. 2017 Dec;
31(21):2175-2185.
PMID: 29196535
Nuclear gene transcription is coordinated with transcript release from the chromatin template and messenger RNA (mRNA) export to the cytoplasm. Here we describe the role of nuclear-localized kinase WNK1 (with...
7.
Burger K, Schlackow M, Potts M, Hester S, Mohammed S, Gullerova M
J Cell Biol
. 2017 Jun;
216(8):2373-2389.
PMID: 28642363
The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates...
8.
Schlackow M, Nojima T, Gomes T, Dhir A, Carmo-Fonseca M, Proudfoot N
Mol Cell
. 2016 Dec;
65(1):25-38.
PMID: 28017589
Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been ascribed to lincRNAs, their synthesis and...
9.
Bhardwaj S, Schlackow M, Rabajdova M, Gullerova M
Nucleic Acids Res
. 2016 Apr;
44(14):6676-92.
PMID: 27084937
Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms...
10.
White E, Schlackow M, Kamieniarz-Gdula K, Proudfoot N, Gullerova M
Nat Struct Mol Biol
. 2014 May;
21(6):552-9.
PMID: 24814348
Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals,...