Marcus Keatinge
Overview
Explore the profile of Marcus Keatinge including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
704
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0
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Recent Articles
1.
Jaroszynska N, Salzinger A, Tsarouchas T, Becker C, Becker T, Lyons D, et al.
J Neurosci
. 2024 Apr;
44(25).
PMID: 38658168
Hexanucleotide repeat expansions within the gene are the most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This disease-causing expansion leads to a reduction...
2.
Keatinge M, Gegg M, Watson L, Mortiboys H, Li N, Dunning M, et al.
Dis Model Mech
. 2023 Mar;
16(6).
PMID: 36951087
Heterozygous variants in GBA1, encoding glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also have a substantial reduction of GCase activity....
3.
Drake L, Keatinge M, Tsarouchas T, Becker C, Lyons D, Becker T
Methods Mol Biol
. 2023 Mar;
2636:263-277.
PMID: 36881306
Larval zebrafish show axonal regrowth over a complex spinal injury site and recovery of function within days after injury. Here we describe a simple protocol to disrupt gene function in...
4.
Leggieri A, Garcia-Gonzalez J, Torres-Perez J, Havelange W, Hosseinian S, Mech A, et al.
Front Neurosci
. 2022 Feb;
16:794653.
PMID: 35210987
Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine kinase family, known to be involved in cell proliferation, differentiation and activation of transcription...
5.
Larbalestier H, Keatinge M, Watson L, White E, Gowda S, Wei W, et al.
J Neurosci
. 2021 Dec;
42(4):702-716.
PMID: 34876467
The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in tetrahydrobiopterin (BH4) synthesis, an essential cofactor in the synthesis of monoaminergic neurotransmitters. To investigate the...
6.
Cavone L, McCann T, Drake L, Aguzzi E, Oprisoreanu A, Pedersen E, et al.
Dev Cell
. 2021 May;
56(11):1617-1630.e6.
PMID: 34033756
Central nervous system injury re-initiates neurogenesis in anamniotes (amphibians and fishes), but not in mammals. Activation of the innate immune system promotes regenerative neurogenesis, but it is fundamentally unknown whether...
7.
Keatinge M, Tsarouchas T, Munir T, Porter N, Larraz J, Gianni D, et al.
PLoS Genet
. 2021 Apr;
17(4):e1009515.
PMID: 33914736
Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages that control post-injury inflammation. However, the mechanistic basis of how macrophages regulate regeneration is poorly understood. To address this...
8.
Brown S, Boussaad I, Jarazo J, Fitzgerald J, Antony P, Keatinge M, et al.
Sci Rep
. 2021 Mar;
11(1):6617.
PMID: 33758225
Recent evidence suggests neurogenesis is on-going throughout life but the relevance of these findings for neurodegenerative disorders such as Parkinson's disease (PD) is poorly understood. Biallelic PINK1 mutations cause early...
9.
Herzog C, Greenald D, Larraz J, Keatinge M, Herrgen L
Biol Open
. 2020 May;
9(5).
PMID: 32366533
Understanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that...
10.
K Soman S, Bazala M, Keatinge M, Bandmann O, Kuznicki J
Biol Open
. 2019 Sep;
8(10).
PMID: 31548178
The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter () using...