Heather Mortiboys
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Explore the profile of Heather Mortiboys including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Bell S, Wareing H, Capriglia F, Hughes R, Barnes K, Hamshaw A, et al.
Mol Psychiatry
. 2024 Sep;
PMID: 39271753
Abnormalities in cellular metabolism are seen early in Alzheimer's disease (AD). Astrocyte support for neuronal function has a high metabolic demand, and astrocyte glucose metabolism plays a key role in...
2.
Rocha E, Chamoli M, Chinta S, Andersen J, Wallis R, Bezard E, et al.
Aging Biol
. 2024 Jul;
1.
PMID: 38978807
Parkinson's disease (PD) is a chronic, neurodegenerative condition characterized by motor symptoms such as bradykinesia, rigidity, and tremor, alongside multiple nonmotor symptoms. The appearance of motor symptoms is linked to...
3.
Au W, Miller-Fleming L, Sanchez-Martinez A, Lee J, Twyning M, Prag H, et al.
Life Sci Alliance
. 2024 Jun;
7(9).
PMID: 38906677
Mitochondrial dysfunction is a common feature of amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD); however, it remains unclear whether this is a cause or consequence of the pathogenic process. Analysing multiple aspects...
4.
Xia Z, Prescott E, Urbanek A, Wareing H, King M, Olerinyova A, et al.
Nat Commun
. 2024 Jun;
15(1):4695.
PMID: 38824138
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer's Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance...
5.
Lee J, Pye N, Ellis L, Vos K, Mortiboys H
Int Rev Neurobiol
. 2024 May;
176:269-325.
PMID: 38802177
Metabolic dysfunction is a hallmark of multiple amyotrophic lateral sclerosis (ALS) models with a majority of ALS patients exhibiting hypermetabolism. The central sites of metabolism in the cell are mitochondria,...
6.
Harvey C, Weinreich M, Lee J, Shaw A, Ferraiuolo L, Mortiboys H, et al.
Heliyon
. 2024 Feb;
10(3):e24975.
PMID: 38317984
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving selective vulnerability of energy-intensive motor neurons (MNs). It has been unclear whether mitochondrial function is an upstream driver or a...
7.
McCarron K, Elcocks H, Mortiboys H, Urbe S, Clague M
Biochem J
. 2024 Feb;
481(4):265-278.
PMID: 38299383
The identification of multiple genes linked to Parkinson's disease (PD) invites the question as to how they may co-operate. We have generated isogenic cell lines that inducibly express either wild-type...
8.
Payne T, Burgess T, Bradley S, Roscoe S, Sassani M, Dunning M, et al.
Brain
. 2023 Dec;
147(1):267-280.
PMID: 38059801
The heterogenous aetiology of Parkinson's disease is increasingly recognized; both mitochondrial and lysosomal dysfunction have been implicated. Powerful, clinically applicable tools are required to enable mechanistic stratification for future precision...
9.
Capriglia F, Burgess T, Bandmann O, Mortiboys H
J Parkinsons Dis
. 2023 Sep;
13(6):851-864.
PMID: 37694310
No abstract available.
10.
Mihaylov S, Castelli L, Lin Y, Gul A, Soni N, Hastings C, et al.
Nat Commun
. 2023 Sep;
14(1):5496.
PMID: 37679383
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a...