Marcus D Hartmann
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Explore the profile of Marcus D Hartmann including associated specialties, affiliations and a list of published articles.
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72
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1135
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Recent Articles
11.
Selim K, Haffner M, Mantovani O, Albrecht R, Zhu H, Hagemann M, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(8):e2205882120.
PMID: 36800386
The PII superfamily consists of widespread signal transduction proteins found in all domains of life. In addition to canonical PII proteins involved in C/N sensing, structurally similar PII-like proteins evolved...
12.
Heim C, Spring A, Kirchgassner S, Schwarzer D, Hartmann M
Biochem Biophys Res Commun
. 2023 Jan;
646:30-35.
PMID: 36701892
In targeted protein degradation, immunomodulatory drugs (IMiDs) or cereblon (CRBN) E3 ligase modulatory drugs (CELMoDs) recruit neo-substrate proteins to the E3 ubiquitin ligase receptor CRBN for ubiquitination and subsequent proteasomal...
13.
Krasavin M, Adamchik M, Bubyrev A, Heim C, Maiwald S, Zhukovsky D, et al.
Eur J Med Chem
. 2022 Dec;
246:114990.
PMID: 36476642
To expand the chemical toolkit for targeted protein degradation, we report the generation of a new series of non-thalidomide Cereblon (CRBN) ligands. Readily available 2-methylidene glutarimide was converted to a...
14.
Heim C, Spring A, Kirchgassner S, Schwarzer D, Hartmann M
Biochem Biophys Res Commun
. 2022 Nov;
637:66-72.
PMID: 36375252
Cereblon (CRBN) is a ubiquitously expressed E3 ligase substrate receptor and a key player in pharmaceutical targeted protein degradation. Despite substantial insight gained into its chemical ligand space that is...
15.
Iskhakova Z, Zhuravleva D, Heim C, Hartmann M, Laykov A, Forchhammer K, et al.
FEBS J
. 2022 Mar;
289(17):5305-5321.
PMID: 35285159
PII proteins are signal processor proteins that regulate the cellular metabolism of Bacteria, Archea and plant chloroplasts typically in response to the cellular nitrogen status. Here, we report the first...
16.
Heim C, Hartmann M
Acta Crystallogr D Struct Biol
. 2022 Mar;
78(Pt 3):290-298.
PMID: 35234143
Cereblon (CRBN) is the substrate receptor of the CRL4 E3 ubiquitin ligase and is a central player in targeted protein degradation. It is the target of the thalidomide-derived immunomodulatory drugs...
17.
Krasavin M, Bubyrev A, Kazantsev A, Heim C, Maiwald S, Zhukovsky D, et al.
J Enzyme Inhib Med Chem
. 2022 Feb;
37(1):527-530.
PMID: 35220840
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all...
18.
Braun V, Hartmann M, Hantke K
FEMS Microbiol Rev
. 2022 Feb;
46(4).
PMID: 35138377
Bacteria are usually iron-deficient because the Fe3+ in their environment is insoluble or is incorporated into proteins. To overcome their natural iron limitation, bacteria have developed sophisticated iron transport and...
19.
Maiwald S, Heim C, Hernandez Alvarez B, Hartmann M
ACS Med Chem Lett
. 2022 Jan;
13(1):148-149.
PMID: 35047112
[This corrects the article DOI: 10.1021/acsmedchemlett.0c00440.].
20.