Marcus D Hartmann
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Explore the profile of Marcus D Hartmann including associated specialties, affiliations and a list of published articles.
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72
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1135
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Recent Articles
1.
Ullrich T, Klimenkova O, Pollmann C, Lasram A, Hatskovska V, Maksymenko K, et al.
PLoS Biol
. 2024 Nov;
22(11):e3002883.
PMID: 39591631
Excessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders. Here, we leverage protein design to create...
2.
Schwab S, Hu Y, van Erp B, Cajili M, Hartmann M, Hernandez Alvarez B, et al.
Nat Commun
. 2024 Sep;
15(1):7950.
PMID: 39261503
Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones...
3.
Hu Y, Schwab S, Deiss S, Escudeiro P, van Heesch T, Joiner J, et al.
Nucleic Acids Res
. 2024 Jun;
52(14):8193-8204.
PMID: 38864377
Histones are essential for genome compaction and transcription regulation in eukaryotes, where they assemble into octamers to form the nucleosome core. In contrast, archaeal histones assemble into dimers that form...
4.
Shevalev R, Bischof L, Sapegin A, Bunev A, Olga G, Kantin G, et al.
Eur J Med Chem
. 2024 Mar;
270:116328.
PMID: 38552426
The vast majority of current cereblon (CRBN) ligands is based on the thalidomide scaffold, relying on glutarimide as the core binding moiety. With this architecture, most of these ligands inherit...
5.
Hartmann M
ACS Med Chem Lett
. 2024 Jan;
15(1):4-5.
PMID: 38229746
Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to...
6.
Fonseca Lopez F, Miao J, Damjanovic J, Bischof L, Braun M, Ling Y, et al.
J Chem Inf Model
. 2023 Nov;
63(21):6925-6937.
PMID: 37917529
The Nrf2 transcription factor is a master regulator of the cellular response to oxidative stress, and Keap1 is its primary negative regulator. Activating Nrf2 by inhibiting the Nrf2-Keap1 protein-protein interaction...
7.
Steinebach C, Bricelj A, Murgai A, Sosic I, Bischof L, Ng Y, et al.
J Med Chem
. 2023 Oct;
66(21):14513-14543.
PMID: 37902300
Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and lenalidomide are the most common cereblon (CRBN) recruiters in proteolysis-targeting chimera (PROTAC) design. However, these CRBN ligands induce the degradation of...
8.
Joiner J, Steinchen W, Mozer N, Kronenberger T, Bange G, Poso A, et al.
J Biol Chem
. 2023 Oct;
299(12):105387.
PMID: 37890783
The expression of virulence factors essential for the invasion of host cells by Salmonella enterica is tightly controlled by a network of transcription regulators. The AraC/XylS transcription factor HilD is...
9.
Alexander L, Durairaj J, Kryshtafovych A, Abriata L, Bayo Y, Bhabha G, et al.
Proteins
. 2023 Jul;
91(12):1571-1599.
PMID: 37493353
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how...
10.
Kuchta R, Heim C, Herrmann A, Maiwald S, Ng Y, Sosic I, et al.
RSC Chem Biol
. 2023 Mar;
4(3):229-234.
PMID: 36908700
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable...