Marco Chiaravalli
Overview
Explore the profile of Marco Chiaravalli including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
751
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Recent Articles
1.
Clerici S, Podrini C, Stefanoni D, Distefano G, Cassina L, Steidl M, et al.
EMBO Mol Med
. 2024 Apr;
16(6):1379-1403.
PMID: 38684863
Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained...
2.
Steidl M, Nigro E, Nielsen A, Pagliarini R, Cassina L, Lampis M, et al.
Nat Metab
. 2023 Mar;
5(3):385-397.
PMID: 36879119
Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are microtubule-based organelles at the cell surface, capable of integrating multiple...
3.
Cordido A, Nunez-Gonzalez L, Martinez-Moreno J, Lamas-Gonzalez O, Rodriguez-Osorio L, Perez-Gomez M, et al.
J Am Soc Nephrol
. 2021 Jun;
32(8):1913-1932.
PMID: 34155062
Background: In autosomal dominant polycystic kidney disease (ADPKD), cyst development and enlargement lead to ESKD. Macrophage recruitment and interstitial inflammation promote cyst growth. TWEAK is a TNF superfamily (TNFSF) cytokine...
4.
Cassina L, Chiaravalli M, Boletta A
FASEB J
. 2020 Apr;
34(5):6493-6507.
PMID: 32239723
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder, characterized by bilateral renal cyst formation. Multiple pathways are de-regulated in cystic epithelia offering good opportunities for therapy. Others...
5.
Nigro E, Distefano G, Chiaravalli M, Matafora V, Castelli M, Pesenti Gritti A, et al.
Sci Rep
. 2019 Nov;
9(1):16640.
PMID: 31719603
Polycystin-1 (PC-1) and 2 (PC-2) are the products of the PKD1 and PKD2 genes, which are mutated in Autosomal Dominant Polycystic Kidney Disease (ADPKD). They form a receptor/channel complex that...
6.
Podrini C, Rowe I, Pagliarini R, Costa A, Chiaravalli M, Di Meo I, et al.
Commun Biol
. 2018 Nov;
1:194.
PMID: 30480096
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in or . Increased glycolysis is a prominent feature of the disease, but how it impacts...
7.
Drusian L, Nigro E, Mannella V, Pagliarini R, Pema M, Costa A, et al.
Cell Rep
. 2018 Aug;
24(5):1093-1104.e6.
PMID: 30067967
Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in...
8.
Iaconis D, Monti M, Renda M, van Koppen A, Tammaro R, Chiaravalli M, et al.
Sci Rep
. 2017 Apr;
7(1):1224.
PMID: 28450740
Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of...
9.
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, et al.
Nat Commun
. 2016 Mar;
7:10786.
PMID: 26931735
Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal...
10.
Chiaravalli M, Rowe I, Mannella V, Quilici G, Canu T, Bianchi V, et al.
J Am Soc Nephrol
. 2015 Nov;
27(7):1958-69.
PMID: 26534924
Autosomal dominant polycystic kidney disease (ADPKD) is an important cause of ESRD for which there exists no approved therapy in the United States. Defective glucose metabolism has been identified as...