Alessandra Boletta
Overview
Explore the profile of Alessandra Boletta including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
2198
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Recent Articles
1.
Boletta A, Caplan M
Physiol Rev
. 2025 Feb;
PMID: 39938884
Polycystic Kidney Disease (PKD) encompasses a class of disorders presenting with bilateral cyst formation in the kidney. PKD can be inherited as a dominant (ADPKD) or a recessive (ARPKD) trait,...
2.
Speranza E, Sorrentino I, Boletta A, Sitia R
Redox Biol
. 2025 Jan;
80:103486.
PMID: 39787899
Aquaporin11 (AQP11) is an endoplasmic reticulum (ER) resident peroxiporin. It allows HO transport from the lumen to the cytosol, guaranteeing redox homeostasis and signaling in and between the two organelles....
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Dalla Torre M, Pittari D, Boletta A, Cassina L, Sitia R, Anelli T
Life Sci Alliance
. 2024 Oct;
7(12).
PMID: 39366760
Upon hormonal stimulation, uterine endometrial stromal cells undergo a dramatic morpho-functional metamorphosis that allows them to secrete large amounts of matrix proteins, cytokines, and growth factors. This step, known as...
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6.
Clerici S, Podrini C, Stefanoni D, Distefano G, Cassina L, Steidl M, et al.
EMBO Mol Med
. 2024 Apr;
16(6):1379-1403.
PMID: 38684863
Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained...
7.
Walker R, Yao Q, Xu H, Maranto A, Swaney K, Ramachandran S, et al.
Nat Commun
. 2023 Oct;
14(1):6513.
PMID: 37845212
Fibrocystin/Polyductin (FPC), encoded by PKHD1, is associated with autosomal recessive polycystic kidney disease (ARPKD), yet its precise role in cystogenesis remains unclear. Here we show that FPC undergoes complex proteolytic...
8.
Donati G, Nicoli P, Verrecchia A, Vallelonga V, Croci O, Rodighiero S, et al.
EMBO Mol Med
. 2023 May;
15(6):e16910.
PMID: 37158102
MYC is a key oncogenic driver in multiple tumor types, but concomitantly endows cancer cells with a series of vulnerabilities that provide opportunities for targeted pharmacological intervention. For example, drugs...
9.
Steidl M, Nigro E, Nielsen A, Pagliarini R, Cassina L, Lampis M, et al.
Nat Metab
. 2023 Mar;
5(3):385-397.
PMID: 36879119
Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are microtubule-based organelles at the cell surface, capable of integrating multiple...
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