Marcella Facchini
Overview
Explore the profile of Marcella Facchini including associated specialties, affiliations and a list of published articles.
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20
Citations
691
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Recent Articles
11.
Kukavica-Ibrulj I, Facchini M, Cigana C, Levesque R, Bragonzi A
Methods Mol Biol
. 2014 May;
1149:757-71.
PMID: 24818948
Murine models of acute and chronic lung infection have been used in studying Pseudomonas aeruginosa for assessing in vivo behavior and for monitoring of the host response. These models provide...
12.
Facchini M, De Fino I, Riva C, Bragonzi A
J Vis Exp
. 2014 Apr;
(85).
PMID: 24686327
A mouse model of chronic airway infection is a key asset in cystic fibrosis (CF) research, although there are a number of concerns regarding the model itself. Early phases of...
13.
Rubino R, Bezzerri V, Favia M, Facchini M, Tebon M, Singh A, et al.
Pflugers Arch
. 2014 Mar;
466(12):2269-78.
PMID: 24595473
Pseudomonas aeruginosa infections of the airway cells decrease apical expression of both wild-type (wt) and F508del CFTR through the inhibition of apical endocytic recycling. CFTR endocytic recycling is known to...
14.
Caretti A, Bragonzi A, Facchini M, De Fino I, Riva C, Gasco P, et al.
Biochim Biophys Acta
. 2013 Oct;
1840(1):586-94.
PMID: 24141140
Background: Sphingolipids take part in immune response and can initiate and/or sustain inflammation. Various inflammatory diseases have been associated with increased ceramide content, and pharmacological reduction of ceramide diminishes inflammation...
15.
Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity
Imperi F, Massai F, Facchini M, Frangipani E, Visaggio D, Leoni L, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(18):7458-63.
PMID: 23569238
Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical applications is an attractive strategy for drug...
16.
Mertz E, Facchini M, Pham A, Gualeni B, De Leonardis F, Rossi A, et al.
J Biol Chem
. 2012 May;
287(26):22030-42.
PMID: 22556422
Diastrophic dysplasia (DTD) is an incurable recessive chondrodysplasia caused by mutations in the SLC26A2 transporter responsible for sulfate uptake by chondrocytes. The mutations cause undersulfation of glycosaminoglycans in cartilage. Studies...
17.
Butini S, Gemma S, Brindisi M, Borrelli G, Fiorini I, Samuele A, et al.
Bioorg Med Chem Lett
. 2011 Jun;
21(13):3935-8.
PMID: 21636271
We investigated some pyrrolobenzoxazepinone (PBOs, 3e-i) analogues of early described effective non-nucleoside inhibitors of HIV-1 reverse transcriptase (RT). Enzymological studies of 3e-i enantiomers, with wild type (wt) RT and some...
18.
Gualeni B, Facchini M, De Leonardis F, Tenni R, Cetta G, Viola M, et al.
Matrix Biol
. 2010 May;
29(6):453-60.
PMID: 20470884
Mutations in the sulfate transporter gene, SCL26A2, lead to cartilage proteoglycan undersulfation resulting in chondrodysplasia in humans; the phenotype is mirrored in the diastrophic dysplasia (dtd) mouse. It remains unclear...
19.
Samuele A, Facchini M, Rotili D, Mai A, Artico M, Armand-Ugon M, et al.
ChemMedChem
. 2008 May;
3(9):1412-8.
PMID: 18465760
We recently reported the synthesis and biological evaluation of a novel series of 5-alkyl-2-(N,N-disubstituted)amino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones (F(2)-N,N-DABOs). These compounds are highly active against both wild-type HIV-1 and the K103N, Y181C, and Y188L...
20.
Mugnaini C, Alongi M, Togninelli A, Gevariya H, Brizzi A, Manetti F, et al.
J Med Chem
. 2007 Dec;
50(26):6580-95.
PMID: 18052319
A series of novel S-DABO analogues, characterized by different substitution patterns at positions 2, 5, and 6 of the heterocyclic ring, were synthesized in a straightforward fashion by means of...